1-(Tetrahydro-pyran-4-yl)-1H-pyrazole-4-carboxylic acid

Base Information

• Chemical Name: 1-(Tetrahydro-pyran-4-yl)-1H-pyrazole-4-carboxylic acid
• CAS No.: 1340372-11-3
• Molecular Formula: C9H12N2O3
• Molecular Weight: 196.206
• Hs Code.: 2933199090
• Mol file: 1340372-11-3.mol

Synonyms:1-(Tetrahydro-pyran-4-yl)-1H-pyrazole-4-carboxylic acid

Chemical Property of 1-(Tetrahydro-pyran-4-yl)-1H-pyrazole-4-carboxylic acid

Chemical Property:

• PSA: 64.35000
• LogP: 0.93280

Purity/Quality:

98%min ^*data from raw suppliers

1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(Tetrahydro-pyran-4-yl)-1H-pyrazole-4-carboxylic acid

There total 5 articles about 1-(Tetrahydro-pyran-4-yl)-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

C11H16N2O3 (1499823-71-0) → 1-(tetrahydropyran-4-yl)-1H-pyrazole-4-carboxylic acid (1340372-11-3)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 50 ℃; for 12h;

Reference yield:

C10H14N2O3 → 1-(tetrahydropyran-4-yl)-1H-pyrazole-4-carboxylic acid (1340372-11-3)

Guidance literature:

With methanol; water; sodium hydroxide; at 25 ℃; for 3h; Inert atmosphere;

Reference yield:

Tetrahydro-pyran-4-ol (2081-44-9) → 1-(tetrahydropyran-4-yl)-1H-pyrazole-4-carboxylic acid (1340372-11-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C

1.2: 15 h / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 14 h / 80 °C

3.1: sodium hydroxide; water / ethanol / 12 h / 50 °C

With water; sodium hydride; caesium carbonate; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

Tetrahydro-pyran-4-ol

toluene-4-sulfonic acid tetrahydropyran-4-yl ester

C₁₁H₁₆N₂O₃

4-bromotetrahydro-2H-pyran

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