4'-Bromo-2'-fluorobiphenyl-4-sulfonyl chloride

Base Information

Chemical Name:4'-Bromo-2'-fluorobiphenyl-4-sulfonyl chloride
CAS No.:677326-82-8
Molecular Formula:C₁₂H₇BrClFO₂S
Molecular Weight:349.608
Hs Code.:
DSSTox Substance ID:DTXSID80373668
Wikidata:Q82161947
Mol file:677326-82-8.mol

Synonyms:4'-bromo-2'-fluorobiphenyl-4-sulfonyl chloride;677326-82-8;4-(4-bromo-2-fluorophenyl)benzenesulfonyl chloride;4'-Bromo-2'-fluoro-[1,1'-biphenyl]-4-sulfonyl chloride;4'-Bromo-2'-fluoro-biphenyl-4-sulfonyl chloride;SCHEMBL12570991;DTXSID80373668;4'-Bromo-2'-fluorobiphenyl-4-sulfonylchloride;3BETA-6BETA-DIHYDROXYOLEAN-12-EN-28-OICACID;4'-Bromo-2'-fluoro-[1,1'-biphenyl]-4-sulfonylchloride

Suppliers and Price of 4'-Bromo-2'-fluorobiphenyl-4-sulfonyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
4'-Bromo-2'-fluoro-[1,1'-biphenyl]-4-sulfonylchloride 95+%
1g
$ 522.00

American Custom Chemicals Corporation
4'-BROMO-2'-FLUOROBIPHENYL-4-SULFONYL CHLORIDE 95.00%
1G
$ 1280.66

AHH
4-Bromo-2-fluorobiphenyl-4-sulfonylchloride 98%
5g
$ 830.00

Total 6 raw suppliers

Chemical Property of 4'-Bromo-2'-fluorobiphenyl-4-sulfonyl chloride

Chemical Property:

PSA：42.52000
LogP:5.26350
XLogP3:4.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:347.90227
Heavy Atom Count:18
Complexity:376

Purity/Quality:

98%min ^*data from raw suppliers

4'-Bromo-2'-fluoro-[1,1'-biphenyl]-4-sulfonylchloride 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=C(C=C(C=C2)Br)F)S(=O)(=O)Cl

Technology Process of 4'-Bromo-2'-fluorobiphenyl-4-sulfonyl chloride

There total 3 articles about 4'-Bromo-2'-fluorobiphenyl-4-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 918638-35-4
4'-bromo-2'-fluorobiphenyl-4-sulfonic acid

: 677326-82-8
4'-bromo-2'-fluorobiphenyl-4-sulfonyl chloride

Guidance literature:: With thionyl chloride; N,N-dimethyl-formamide; for 4h; Heating;
DOI:10.1021/jm051236m

Reference yield:

: 41604-19-7
1-bromo-3-fluoro-4-phenylbenzene

: 677326-82-8
4'-bromo-2'-fluorobiphenyl-4-sulfonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / chlorosulfonic acid / CHCl₃ / 4 h / 20 °C

2: 88 percent / thionyl chloride / DMF / 4 h / Heating

With chlorosulfonic acid; thionyl chloride; N,N-dimethyl-formamide; In chloroform;
DOI:10.1021/jm051236m

Reference yield:

: 41604-19-7
1-bromo-3-fluoro-4-phenylbenzene

: 677326-82-8
4'-bromo-2'-fluorobiphenyl-4-sulfonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: ClSO₃H / CHCl₃ / 20 °C

2: SOCl₂ / dimethylformamide / Heating

With chlorosulfonic acid; thionyl chloride; In chloroform; N,N-dimethyl-formamide; 1: sulfonation / 2: Chlorination;
DOI:10.1021/jm9903141