6-Fluoro-5-Methoxy-2,3-dihydro-1h-inden-1-one

Base Information

• Chemical Name: 6-Fluoro-5-Methoxy-2,3-dihydro-1h-inden-1-one
• CAS No.: 295779-82-7
• Molecular Formula: C10H9FO2
• Molecular Weight: 180.1756632
• Mol file: 295779-82-7.mol

Synonyms:6-Fluoro-5-Methoxy-2,3-dihydro-1h-inden-1-one;6-Fluoro-5-methoxy-indan-1-one

Chemical Property of 6-Fluoro-5-Methoxy-2,3-dihydro-1h-inden-1-one

Chemical Property:

• Boiling Point: 312.0±42.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.257±0.06 g/cm3(Predicted)
• LogP: 1.96320
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

6-Fluoro-5-methoxy-2,3-dihydro-1H-inden-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Fluoro-5-Methoxy-2,3-dihydro-1h-inden-1-one

There total 2 articles about 6-Fluoro-5-Methoxy-2,3-dihydro-1h-inden-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methoxy-1-indanone (5111-70-6) → 6-fluoro-5-methoxy-2,3-dihydro-1H-inden-1-one (295779-82-7) + 4-fluoro-5-methoxy-2,3-dihydro-1H-inden-1-one (295779-81-6)

Guidance literature:

With 1-fluoro-4-hydroxy-1,4-diazoniabicyclo[2,2,2]octane-1,4-bis(tetrafluoroborate); In acetonitrile; Title compound not separated from byproducts.; Heating;

DOI:10.1039/b003488f

Reference yield:

5-methoxy-1-indanone (5111-70-6) → 2-fluoro-5-methoxy-2,3-dihydro-1H-inden-1-one + 6-fluoro-5-methoxy-2,3-dihydro-1H-inden-1-one (295779-82-7) + 4-fluoro-5-methoxy-2,3-dihydro-1H-inden-1-one (295779-81-6)

Guidance literature:

With Selectfluor; at 70 ℃; for 18h; Ionic liquid;

DOI:10.3390/molecules14072394

Reference yield: 84.0%

phenylmagnesium bromide + 6-fluoro-5-methoxy-2,3-dihydro-1H-inden-1-one (295779-82-7) → 6-fluoro-5-methoxy-1-phenyl-1H-indene

Guidance literature:

In tetrahydrofuran; diethyl ether; Heating;

DOI:10.1021/jm040889k

upstream raw materials:

5-methoxy-1-indanone

Downstream raw materials:

C₁₄H₁₇FO₃

ethyl 3-(3,5-difluoro-4-hydroxyphenyl)-2-ethoxypropanoate

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