2-[4-(4-Bromo-phenyl)-piperazin-1-YL]-ethylamine

Base Information

• Chemical Name: 2-[4-(4-Bromo-phenyl)-piperazin-1-YL]-ethylamine
• CAS No.: 199616-96-1
• Molecular Formula: C₁₂H₁₈BrN₃
• Molecular Weight: 284.199
• DSSTox Substance ID: DTXSID50363955
• Wikidata: Q82147712
• Mol file: 199616-96-1.mol

Synonyms:199616-96-1;2-[4-(4-BROMO-PHENYL)-PIPERAZIN-1-YL]-ETHYLAMINE;2-[4-(4-bromophenyl)piperazin-1-yl]ethanamine;2-(4-(4-BROMOPHENYL)PIPERAZIN-1-YL)ETHANAMINE;SCHEMBL5185973;DTXSID50363955;AKOS022357273;2-[4-(4-bromophenyl)piperazin-1-yl]ethylamine;2-[4-(4-bromophenyl)piperazin-1-yl]ethan-1-amine

Chemical Property of 2-[4-(4-Bromo-phenyl)-piperazin-1-YL]-ethylamine

Chemical Property:

• PSA: 32.50000
• LogP: 2.23300
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 283.06841
• Heavy Atom Count: 16
• Complexity: 196

Purity/Quality:

98% ^*data from raw suppliers

2-(4-(4-bromophenyl)piperazin-1-yl)ethanamine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1CCN)C2=CC=C(C=C2)Br

Technology Process of 2-[4-(4-Bromo-phenyl)-piperazin-1-YL]-ethylamine

There total 3 articles about 2-[4-(4-Bromo-phenyl)-piperazin-1-YL]-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-Bromophenyl)Piperazine Monohydrochloride → 4-(4-bromophenyl)-1-piperazineethanamine (199616-96-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 20 h / Reflux

2: hydrazine hydrate / ethanol / 1 h / Reflux

With potassium carbonate; hydrazine hydrate; In ethanol; acetone;

DOI:10.1021/acs.jmedchem.9b01085

Reference yield:

2-(2-(4-(4-bromophenyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione → 4-(4-bromophenyl)-1-piperazineethanamine (199616-96-1)

Guidance literature:

With hydrazine hydrate; In ethanol; for 1h; Reflux;

DOI:10.1021/acs.jmedchem.9b01085

Reference yield:

→ 4-(4-bromophenyl)-1-piperazineethanamine (199616-96-1)

Guidance literature:

Refernces

• 1、 -. "Alkylaminobenzothiazole and -benzoxazole derivatives". . . Retrieved 2008/06/13.