2-Amino-N,N-diethyl-3-phenylpropanamidehydrochloride

Base Information

• Chemical Name: 2-Amino-N,N-diethyl-3-phenylpropanamidehydrochloride
• CAS No.: 1236267-49-4
• Molecular Formula: C₁₃H₂₀N₂O*ClH
• Molecular Weight: 256.776
• Hs Code.: 2924299090
• Mol file: 1236267-49-4.mol

Synonyms:2-Amino-N,N-diethyl-3-phenylpropanamidehydrochloride

Chemical Property of 2-Amino-N,N-diethyl-3-phenylpropanamidehydrochloride

Chemical Property:

• PSA: 46.33000
• LogP: 2.92710

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-N,N-diethyl-3-phenylpropanamideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-N,N-diethyl-3-phenylpropanamidehydrochloride

There total 2 articles about 2-Amino-N,N-diethyl-3-phenylpropanamidehydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-diethyl-(S)-2-(tert-butoxycarbonyl)amino-3-phenylpropanamide (120125-19-1) → H-Phe-N(C2H5)2*HCl (1236267-49-4)

Guidance literature:

With hydrogenchloride; for 0.5h; Ambient temperature;

DOI:10.1248/cpb.36.4834

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → H-Phe-N(C2H5)2*HCl (1236267-49-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-hydroxybenzotriazole, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, N-methylmorpholine / dimethylformamide / 5 °C

2: 4N HCl-dioxane / 0.5 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.36.4834

Reference yield:

H-Phe-N(C2H5)2*HCl (1236267-49-4) → Tyr-D-Arg-Phe-N(CH2CH3)2 (111076-34-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 1-hydroxybenzotriazole, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, N-methylmorpholine / dimethylformamide / 5 °C

2: 4N HCl-dioxane / 0.5 h / Ambient temperature

3: 1-hydroxybenzotriazole, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, N-methylmorpholine / dimethylformamide / 5 °C

4: 4N HCl-dioxane / 0.5 h / Ambient temperature

5: H₂ / 10percent Pd-C / methanol; H₂O / 16 h

With 4-methyl-morpholine; hydrogenchloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1248/cpb.36.4834

upstream raw materials:

N,N-diethyl-(S)-2-(tert-butoxycarbonyl)amino-3-phenylpropanamide

N-tert-butoxycarbonyl-L-phenylalanine

Downstream raw materials:

Boc-Tyr-D-Arg(NO₂)-Phe-N(C₂H₅)2

Tyr-D-Arg-Phe-N(CH₂CH₃)2

(S)-N¹,N¹-diethyl-3-phenylpropane-1,2-diamine