Duvelisib int

Base Information

Chemical Name:Duvelisib int
CAS No.:1350643-72-9
Molecular Formula:C17H15ClN2O
Molecular Weight:298.772
Hs Code.:
Mol file:1350643-72-9.mol

Synonyms:Duvelisib int;(S)-3-(1-aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one;3-[(1S)-1-aminoethyl]-8-chloro-2-phenyl-1,2-dihydroisoquinolin-1-one;3-[(1S)-1-aminoethyl]-8-chloro-2-phenyl-1(2H)-Isoquinolinone;1(2H)-Isoquinolinone, 3-[(1S)-1-aminoethyl]-8-chloro-2-phenyl-;Duvelisib int (IPi-145 int )

Suppliers and Price of Duvelisib int

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-[(1s)-1-Aminoethyl]-8-Chloro-2-Phenyl-1,2-Dihydroisoquinolin-1-One
100mg
$ 155.00

Crysdot
(S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one 95+%
1g
$ 527.00

Crysdot
(S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one 95+%
5g
$ 1583.00

Chemenu
(S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one 95%
5g
$ 1491.00

Chemenu
(S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one 95%
1g
$ 497.00

American Custom Chemicals Corporation
(S)-3-(1-AMINOETHYL)-8-CHLORO-2-PHENYLISOQUINOLIN-1(2H)-ONE 95.00%
5MG
$ 496.95

Ambeed
(S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one 98+%
5g
$ 330.00

Ambeed
(S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one 98+%
1g
$ 94.00

Ambeed
(S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one 98+%
250mg
$ 37.00

Ambeed
(S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one 98+%
100mg
$ 25.00

Total 20 raw suppliers

Chemical Property of Duvelisib int

Chemical Property:

Boiling Point:477.9±45.0 °C(Predicted)
PKA:10.59±0.29(Predicted)
Density:1.296±0.06 g/cm3(Predicted)
Storage Temp.:Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%, ^*data from raw suppliers

3-[(1s)-1-Aminoethyl]-8-Chloro-2-Phenyl-1,2-Dihydroisoquinolin-1-One ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Duvelisib int

There total 10 articles about Duvelisib int which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1386861-47-7
tert-butyl (S)-(4-(3-chloro-2-(phenylcarbamoyl)phenyl)-3-oxobutane-2-yl)carbamate

: 1350643-72-9
(S)-3-(1-aminoethyl)-8-chloro-2-phenylisoquinoline-1(2H)-one

Guidance literature:: With hydrogenchloride; In isopropyl alcohol; at 70 ℃; for 8h;

Reference yield: 78.6%

: 1386861-46-6
2-chloro-6-methyl-N-phenylbenzamide

: 146553-06-2,87694-49-3
tert-butyl {(S)-1-[methoxy(methyl)amino]-1-oxopropan-2-yl}carbamate

: 1350643-72-9
(S)-3-(1-aminoethyl)-8-chloro-2-phenylisoquinoline-1(2H)-one

Guidance literature:: 2-chloro-6-methyl-N-phenylbenzamide; With n-butyllithium; In tetrahydrofuran; at -30 ℃; for 1h; Inert atmosphere;

tert-butyl {(S)-1-[methoxy(methyl)amino]-1-oxopropan-2-yl}carbamate; With isopropylmagnesium chloride; In tetrahydrofuran; at -30 - -15 ℃; Inert atmosphere;

With hydrogenchloride; water; In methanol; at 95 ℃; for 14h;

Reference yield:

: 62-53-3
aniline

: 1350643-72-9
(S)-3-(1-aminoethyl)-8-chloro-2-phenylisoquinoline-1(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

1.2: 2 h / 20 - 40 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -30 - -10 °C / Inert atmosphere

2.2: 1 h / -30 - -10 °C / Inert atmosphere

2.3: 1 h / Reflux

With n-butyllithium; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; dichloromethane;