4-Fluoro-5-isoquinolinesulfonyl chloride hydrochloride (1:1)

Base Information

• Chemical Name: 4-Fluoro-5-isoquinolinesulfonyl chloride hydrochloride (1:1)
• CAS No.: 906820-08-4
• Molecular Formula: C9H6Cl2FNO2S
• Molecular Weight: 316.5639032
• Mol file: 906820-08-4.mol

Synonyms:4-Fluoro-5-isoquinolinesulfonyl chloride hydrochloride (1:1)

Chemical Property of 4-Fluoro-5-isoquinolinesulfonyl chloride hydrochloride (1:1)

Chemical Property:

• PSA: 55.41000
• LogP: 4.18420

Purity/Quality:

90% ^*data from raw suppliers

4-Fluoroisoquinoline-5-sulfonylchloridehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Fluoro-5-isoquinolinesulfonyl chloride hydrochloride (1:1)

There total 10 articles about 4-Fluoro-5-isoquinolinesulfonyl chloride hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-fluoroisoquinoline-5-sulfonic acid (906820-10-8) → 4-fluoroisoquinoline-5-sulfonyl chloride hydrochloride (906820-08-4)

Guidance literature:

With bis(trichloromethyl) carbonate; Triphenylphosphine oxide; In ethyl acetate; at 50 ℃; for 5h; Solvent; Temperature;

Reference yield: 55.0%

4--fluoroisoquinoline (394-67-2) → C9H5ClFNO2S*ClH (1334294-10-8) + 4-fluoroisoquinoline-5-sulfonyl chloride hydrochloride (906820-08-4)

Guidance literature:

4--fluoroisoquinoline; With sulfuric acid; at 10 - 40 ℃; for 0.5h;

With sulfur trioxide; at 20 - 45 ℃; for 12h;

With hydrogenchloride; thionyl chloride; sodium hydrogencarbonate; more than 3 stages; Product distribution / selectivity;

Reference yield: 45.4%

sodium sulfate anhydrate + 4-fluoroisoquinoline sulfate (906820-09-5) + disulfuric acid (7783-05-3) → 4-fluoroisoquinoline-5-sulfonyl chloride hydrochloride (906820-08-4)

Guidance literature:

With thionyl chloride; sodium hydrogencarbonate; In dichloromethane; water; ethyl acetate;

upstream raw materials:

4-fluoroisoquinoline sulfate

disulfuric acid

4--fluoroisoquinoline

4-fluoroisoquinoline-5-sulfonic acid

Downstream raw materials:

4-fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]isoquinoline hydrochloride

ripasudil