Technology Process of Spiro[azuleno[4,5-b]furan-9(2H),3'-[3H]benz[1,8]- azuleno[4,5-b]furan]-2,2',8,9'(1'H,3H,4'H)- tetrone,3a,4,5,5',5'a,6,6',6a,7,7',7'a,8',9a,9b,- 10'a,10'b-hexadecahydro-5'a-hydroxy-1',3,6,- 8'-tetrakis(methylene)-
There total 1 articles about Spiro[azuleno[4,5-b]furan-9(2H),3'-[3H]benz[1,8]- azuleno[4,5-b]furan]-2,2',8,9'(1'H,3H,4'H)- tetrone,3a,4,5,5',5'a,6,6',6a,7,7',7'a,8',9a,9b,- 10'a,10'b-hexadecahydro-5'a-hydroxy-1',3,6,- 8'-tetrakis(methylene)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 16 steps
1.1: 3-chloro-benzenecarboperoxoic acid / chloroform / -20 - 0 °C
2.1: aluminum isopropoxide / toluene / 5 h / 140 °C / Sealed tube
3.1: Dess-Martin periodane / dichloromethane / 1 h / 0 °C
4.1: copper(l) cyanide / tetrahydrofuran / 0 °C
4.2: 2 h / -78 °C
5.1: boron trifluoride diethyl etherate / chloroform; diethyl ether / 0 °C
5.2: 1.5 h / 0 - 30 °C
6.1: 2,6-dimethylpyridine / dichloromethane / 0.17 h / 0 °C
7.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C
7.2: 2 h / -55 °C
8.1: cerium(III) chloride heptahydrate; sodium tetrahydroborate / methanol / 0.67 h / 0 °C
9.1: dihydrogen peroxide / tetrahydrofuran; water / 0 - 25 °C
10.1: lithium diisopropyl amide / tetrahydrofuran / 0.83 h / -78 °C / Inert atmosphere
10.2: 2 h / -78 - -40 °C / Inert atmosphere
10.3: 1.5 h / 0 °C
11.1: triethylamine / dichloromethane / 0.33 h / 0 °C
12.1: neat (no solvent) / 10 h / 60 °C / Inert atmosphere
13.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C
14.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 0 °C
15.1: pyridinium chlorochromate / dichloromethane / 1 h / 0 °C
16.1: dicyclohexyl-carbodiimide; copper(l) chloride / dichloromethane / 4 h / 80 °C / Sealed tube
With
2,6-dimethylpyridine; sodium tetrahydroborate; cerium(III) chloride heptahydrate; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; dihydrogen peroxide; copper(l) cyanide; aluminum isopropoxide; Dess-Martin periodane; triethylamine; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; pyridinium chlorochromate; copper(l) chloride; lithium hexamethyldisilazane; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; water; toluene;
4.2: |Michael Addition / 12.1: |Diels-Alder Cycloaddition;
DOI:10.1002/chem.201204292
