SPIRO[1,3-DIOXOLANE-2,1'(2'H)-NAPHTHALENE]-5'-CARBOXYLIC ACID, 3',4',6',7',8',8'A-HEXAHYDRO-8'A-METHYL-6'-OXO-, METHYL ESTER (9CI) (4'AR, 5'R, 8'AR)

Base Information Edit

Chemical Name:SPIRO[1,3-DIOXOLANE-2,1'(2'H)-NAPHTHALENE]-5'-CARBOXYLIC ACID, 3',4',6',7',8',8'A-HEXAHYDRO-8'A-METHYL-6'-OXO-, METHYL ESTER (9CI) (4'AR, 5'R, 8'AR)
CAS No.:287401-07-4
Molecular Formula:C15H22O5
Molecular Weight:282.334
Hs Code.:
Mol file:287401-07-4.mol

Synonyms:SPIRO[1,3-DIOXOLANE-2,1'(2'H)-NAPHTHALENE]-5'-CARBOXYLIC ACID, 3',4',6',7',8',8'A-HEXAHYDRO-8'A-METHYL-6'-OXO-, METHYL ESTER (9CI) (4'AR, 5'R, 8'AR);SPIRO[1,3-DIOXOLANE-2,1'(2'H)-NAPHTHALENE]-5'-CARBOXYLIC ACID, 3',4',6',7',8',8'A-HEXAHYDRO-8'A-METHYL-6'-OXO-, METHYL ESTER (4'AR, 5'R, 8'AR);Spiro[1,3-dioxolane-2,1'(2'H)-naphthalene]-5'-carboxylic acid, 3',4',6',7',8',8'a-hexahydro-8'a-methyl-6'-oxo-, methyl ester (9CI) (4'aR, 5'R, 8'aR)

Suppliers and Price of SPIRO[1,3-DIOXOLANE-2,1'(2'H)-NAPHTHALENE]-5'-CARBOXYLIC ACID, 3',4',6',7',8',8'A-HEXAHYDRO-8'A-METHYL-6'-OXO-, METHYL ESTER (9CI) (4'AR, 5'R, 8'AR)

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(4'AR, 5'R, 8'AR)-3',4',6',7',8',8'ALPHA-HEXAHYDRO-8'ALPHA-METHYL-6'-OXO-SPIRO[1,3-DIOXOLANE-2,1'(2'H)-NAPHTHALENE]-5'-CARBOXYLIC ACID METHYL ESTER 95.00%
5MG
$ 498.44

Total 2 raw suppliers

Chemical Property of SPIRO[1,3-DIOXOLANE-2,1'(2'H)-NAPHTHALENE]-5'-CARBOXYLIC ACID, 3',4',6',7',8',8'A-HEXAHYDRO-8'A-METHYL-6'-OXO-, METHYL ESTER (9CI) (4'AR, 5'R, 8'AR) Edit

Chemical Property:

Boiling Point:391.644oC at 760 mmHg
Flash Point:201.761oC
PSA：61.83000
Density:1.205g/cm3
LogP:1.68800

Purity/Quality:

95% ^*data from raw suppliers

(4'AR, 5'R, 8'AR)-3',4',6',7',8',8'ALPHA-HEXAHYDRO-8'ALPHA-METHYL-6'-OXO-SPIRO[1,3-DIOXOLANE-2,1'(2'H)-NAPHTHALENE]-5'-CARBOXYLIC ACID METHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of SPIRO[1,3-DIOXOLANE-2,1'(2'H)-NAPHTHALENE]-5'-CARBOXYLIC ACID, 3',4',6',7',8',8'A-HEXAHYDRO-8'A-METHYL-6'-OXO-, METHYL ESTER (9CI) (4'AR, 5'R, 8'AR)

There total 4 articles about SPIRO[1,3-DIOXOLANE-2,1'(2'H)-NAPHTHALENE]-5'-CARBOXYLIC ACID, 3',4',6',7',8',8'A-HEXAHYDRO-8'A-METHYL-6'-OXO-, METHYL ESTER (9CI) (4'AR, 5'R, 8'AR) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 17640-15-2
methyl cyanoformate

: 117556-90-8
(8aR)-3,4,8,8a-tetrahydro-8a-methyl-1,6(2H,7H)-naphthalenedione 1-ethylene ketal

: 287401-07-4
CH₂CH₂COCHC₂CH₃CO(CH₂)3CH₂CH₂OCO₂CH₃H

Guidance literature:: (8aR)-3,4,8,8a-tetrahydro-8a-methyl-1,6(2H,7H)-naphthalenedione 1-ethylene ketal; With lithium; tert-butyl alcohol; In diethyl ether; ammonia; at -78 - -45 ℃; for 0.5h;

With isoprene; In diethyl ether; ammonia; at -78 - -45 ℃;

methyl cyanoformate; In diethyl ether; at -78 - 0 ℃; for 2h; Further stages.;
DOI:10.1021/jo0159035

Reference yield: 72.0%

: 17640-15-2
methyl cyanoformate

: 287401-07-4
CH₂CH₂COCHC₂CH₃CO(CH₂)3CH₂CH₂OCO₂CH₃H

Guidance literature:: (8aR)-3,4,8,8a-tetrahydro-8a-methyl-1,6(2H,7H)-naphthalenedione 1-ethylene ketal; With ammonia; lithium; tert-butyl alcohol; In diethyl ether; at -78 ℃; for 3h; Heating / reflux;

methyl cyanoformate; In diethyl ether; at -78 - 20 ℃; for 2h;