methyl (2S)-1-(2-methoxy-2-oxoacetyl)pyrrolidine-2-carboxylate

Base Information

Chemical Name:methyl (2S)-1-(2-methoxy-2-oxoacetyl)pyrrolidine-2-carboxylate
CAS No.:139419-63-9
Molecular Formula:C9H13NO5
Molecular Weight:215.206
Hs Code.:2933990090
European Community (EC) Number:696-248-8
DSSTox Substance ID:DTXSID00448443
Nikkaji Number:J493.710D
Wikidata:Q76416221
Mol file:139419-63-9.mol

Synonyms:139419-63-9;methyl (2S)-1-(2-methoxy-2-oxoacetyl)pyrrolidine-2-carboxylate;Methyl (2S)-1-(2-methoxy-2-oxoacetyl)-pyrrolidine-2-carboxylate;(S)-Methyl 1-(2-methoxy-2-oxoacetyl)pyrrolidine-2-carboxylate;SCHEMBL2006947;DTXSID00448443;AKOS015991365;EG-0031;A898471;(S)-Methyl1-(2-methoxy-2-oxoacetyl)pyrrolidine-2-carboxylate;1-(2-Methoxy-1,2-dioxoethyl)pyrrolidine-2alpha-carboxylic acid methyl ester

Suppliers and Price of methyl (2S)-1-(2-methoxy-2-oxoacetyl)pyrrolidine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Methyl (2S)-1-(2-methoxy-2-oxoacetyl)-pyrrolidine-2-carboxylate 97%
1g
$ 328.00

Matrix Scientific
Methyl (2S)-1-(2-methoxy-2-oxoacetyl)-pyrrolidine-2-carboxylate 97%
500mg
$ 262.00

Matrix Scientific
Methyl (2S)-1-(2-methoxy-2-oxoacetyl)-pyrrolidine-2-carboxylate 97%
5g
$ 747.00

Crysdot
(S)-Methyl1-(2-methoxy-2-oxoacetyl)pyrrolidine-2-carboxylate 95+%
5g
$ 462.00

Total 3 raw suppliers

Chemical Property of methyl (2S)-1-(2-methoxy-2-oxoacetyl)pyrrolidine-2-carboxylate

Chemical Property:

PSA：72.91000
LogP:-0.73870
XLogP3:0.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:215.07937252
Heavy Atom Count:15
Complexity:288

Purity/Quality:

97% ^*data from raw suppliers

Methyl (2S)-1-(2-methoxy-2-oxoacetyl)-pyrrolidine-2-carboxylate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1CCCN1C(=O)C(=O)OC
Isomeric SMILES:COC(=O)[C@@H]1CCCN1C(=O)C(=O)OC

Technology Process of methyl (2S)-1-(2-methoxy-2-oxoacetyl)pyrrolidine-2-carboxylate

There total 4 articles about methyl (2S)-1-(2-methoxy-2-oxoacetyl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 5781-53-3
monomethyl oxalyl chloride

: 2133-40-6
L-proline methyl ester monohydrochloride

: 139419-63-9
methyl (2S)-1-(1,2-dioxo-2-methoxyethyl)-2-pyrrolidinecarboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1.5h;
DOI:10.1021/jm010556c

Reference yield: 88.0%

: 5781-53-3
monomethyl oxalyl chloride

: 2577-48-2
methyl (2S)-pyrrolidine carboxylate

: 139419-63-9
methyl (2S)-1-(1,2-dioxo-2-methoxyethyl)-2-pyrrolidinecarboxylate

Guidance literature:: In dichloromethane; at 0 ℃; for 1.5h;

Reference yield:

: 2133-40-6
L-proline methyl ester monohydrochloride

: 139419-63-9
methyl (2S)-1-(1,2-dioxo-2-methoxyethyl)-2-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.25 h / 0 °C

2: triethylamine / dichloromethane / 1.5 h / 0 °C

With triethylamine; In dichloromethane;