2-Bromo-10H-indolo[3,2-b]quinoline

Base Information

• Chemical Name: 2-Bromo-10H-indolo[3,2-b]quinoline
• CAS No.: 308110-69-2
• Molecular Formula: C₁₅H₉BrN₂
• Molecular Weight: 297.154
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00454428
• Nikkaji Number: J1.394.084C
• Wikidata: Q82275947
• Mol file: 308110-69-2.mol

Synonyms:2-Bromo-10H-indolo[3,2-b]quinoline;308110-69-2;2-bromoquindoline;2-Bromo-10H-quindoline;SCHEMBL2112432;DTXSID00454428

Chemical Property of 2-Bromo-10H-indolo[3,2-b]quinoline

Chemical Property:

• Boiling Point: 514.8±30.0 °C(Predicted)
• PKA: 14?+-.0.40(Predicted)
• PSA: 28.68000
• Density: 1.655±0.06 g/cm3(Predicted)
• LogP: 4.63180
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 295.99491
• Heavy Atom Count: 18
• Complexity: 322

Purity/Quality:

98%Min ^*data from raw suppliers

2-Bromo-10H-indolo[3,2-b]quinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C3=C(N2)C=C4C=C(C=CC4=N3)Br

Technology Process of 2-Bromo-10H-indolo[3,2-b]quinoline

There total 13 articles about 2-Bromo-10H-indolo[3,2-b]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-bromo-10H-indolo[3,2-b]quinoline-11-carboxylic acid (241470-53-1) → 2-bromo-10H-indolo[3,2-b]quinoline (308110-69-2)

Guidance literature:

In various solvent(s); at 250 - 300 ℃;

DOI:10.1016/S0960-894X(00)00378-4

Reference yield: 68.0%

6-bromo-2-(2-nitro-phenyl)-quinoline (874212-44-9) → 2-bromo-10H-indolo[3,2-b]quinoline (308110-69-2)

Guidance literature:

With triethyl phosphite; for 4h; Heating;

DOI:10.1016/j.tetlet.2005.11.007

Reference yield:

5-bromoindoxyl diacetate (33588-54-4) → 2-bromo-10H-indolo[3,2-b]quinoline (308110-69-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. KOH / 240 h / 20 °C

2: diphenyl ether / 6 h / 250 °C

With potassium hydroxide; In diphenylether;

DOI:10.1021/jm010929+

upstream raw materials:

2-bromo-10H-indolo[3,2-b]quinoline-11-carboxylic acid

6-bromo-2-(2-nitro-phenyl)-quinoline

5-bromoindoxyl diacetate

indole-2,3-dione