5-Amino-1,3,3-trimethyl-2-oxindole

Base Information

• Chemical Name: 5-Amino-1,3,3-trimethyl-2-oxindole
• CAS No.: 953048-71-0
• Molecular Formula: C11H14N2O
• Molecular Weight: 190.24166
• Hs Code.: 2933790090
• Mol file: 953048-71-0.mol

Synonyms:5-Amino-1,3,3-trimethyl-2-oxindole;5-Amino-1,3,3-trimethyl-2...;5-AMino-1,3,3-triMethyl-2-oxoindoline;5-Amino-1,3,3-trimethyl-indolin-2-one;5-amino-1,3,3-trimethyl-2,3-dihydro-1H-indol-2-one

Chemical Property of 5-Amino-1,3,3-trimethyl-2-oxindole

Chemical Property:

• PSA: 46.33000
• LogP: 2.16900

Purity/Quality:

97% ^*data from raw suppliers

5-Amino-1,3,3-trimethyl-indolin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Amino-1,3,3-trimethyl-2-oxindole

There total 2 articles about 5-Amino-1,3,3-trimethyl-2-oxindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1,3-dihydro-1,3,3-trimethyl-5-nitro-2H-indole-2-one (120791-55-1) → 5-amino-1,3,3-trimethyl-1,3-dihydro-2H-indol-2-one (953048-71-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; ethyl acetate; at 20 ℃;

DOI:10.1021/jo501665e

Reference yield:

1,3,3-trimethyl-1,3-dihydro-2H-indol-2-one (20200-86-6) → 5-amino-1,3,3-trimethyl-1,3-dihydro-2H-indol-2-one (953048-71-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / 65 percent HNO₃ / acetic acid / 24 h / Ambient temperature

2: 57.8 g / hydrogen / 10 percent Pd/C / methanol / 760 Torr / Ambient temperature

With hydrogen; nitric acid; palladium on activated charcoal; In methanol; acetic acid;

DOI:10.1021/jm00127a015

Reference yield: 76.0%

tetrahydroxydiboron (13675-18-8) + 5-amino-1,3,3-trimethyl-1,3-dihydro-2H-indol-2-one (953048-71-0) → 1,3,3-trimethyl-2-oxoindolin-5-ylboronic acid

Guidance literature:

5-amino-1,3,3-trimethyl-1,3-dihydro-2H-indol-2-one; With hydrogenchloride; In water; at 20 ℃; for 0.0166667h;

With sodium nitrite; In water; at 0 ℃; for 0.25h;

tetrahydroxydiboron; With sodium acetate; In water; at 20 ℃; for 0.333333h;

DOI:10.1021/jo501665e

upstream raw materials:

1,3-dihydro-1,3,3-trimethyl-5-nitro-2H-indole-2-one

1,3,3-trimethyl-1,3-dihydro-2H-indol-2-one