ASISCHEM D29214

Base Information

• Chemical Name: ASISCHEM D29214
• CAS No.: 928708-16-1
• Molecular Formula: C₁₃H₁₂N₂O₃
• Molecular Weight: 244.25
• Mol file: 928708-16-1.mol

Synonyms:ASISCHEM D29214;1H-PYRROLE-3-CARBOXALDEHYDE, 2,5-DIMETHYL-1-(2-NITROPHENYL)-;2,5-DIMETHYL-1-(2-NITROPHENYL)-1H-PYRROLE-3-CARBOXALDEHYDE

Chemical Property of ASISCHEM D29214

Chemical Property:

• PSA: 67.82000
• LogP: 3.33800

Purity/Quality:

99% ^*data from raw suppliers

2,5-DIMETHYL-1-(2-NITROPHENYL)-1H-PYRROLE-3-CARBOXALDEHYDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ASISCHEM D29214

There total 3 articles about ASISCHEM D29214 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2,5-dimethyl-1-(2-nitrophenyl)pyrrole (2405-03-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,5-dimethyl-1-(2-nitrophenyl)-1H-pyrrole-3-carbaldehyde (928708-16-1)

Guidance literature:

With trichlorophosphate; In neat (no solvent); at 0 - 100 ℃;

DOI:10.1007/s00044-016-1517-y

Reference yield:

2-nitro-aniline (88-74-4) → 2,5-dimethyl-1-(2-nitrophenyl)-1H-pyrrole-3-carbaldehyde (928708-16-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 0.75 h / 110 - 115 °C

2: trichlorophosphate / neat (no solvent) / 0 - 100 °C

With acetic acid; trichlorophosphate; In neat (no solvent); 1: |Paal-Knorr Pyrrole Synthesis / 2: |Vilsmeier-Haack Formylation;

DOI:10.1007/s00044-016-1517-y

Reference yield:

2,5-hexanedione (110-13-4) → 2,5-dimethyl-1-(2-nitrophenyl)-1H-pyrrole-3-carbaldehyde (928708-16-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 0.75 h / 110 - 115 °C

2: trichlorophosphate / neat (no solvent) / 0 - 100 °C

With acetic acid; trichlorophosphate; In neat (no solvent); 1: |Paal-Knorr Pyrrole Synthesis / 2: |Vilsmeier-Haack Formylation;

DOI:10.1007/s00044-016-1517-y

upstream raw materials:

2,5-dimethyl-1-(2-nitrophenyl)pyrrole

N,N-dimethyl-formamide

2-nitro-aniline

2,5-hexanedione