(r)-2-methyl-n-[(1e)-2,2,2-trifluoroethylidene]propane-2-sulfinamide

Base Information

• Chemical Name: (r)-2-methyl-n-[(1e)-2,2,2-trifluoroethylidene]propane-2-sulfinamide
• CAS No.: 1219607-85-8
• Molecular Formula: C₆H₁₀F₃NOS
• Molecular Weight: 201.213
• Mol file: 1219607-85-8.mol

Synonyms:(r)-2-methyl-n-[(1e)-2,2,2-trifluoroethylidene]propane-2-sulfinamide;(R)-2-Methyl-N-(2,2,2-trifluoroethylidene)propane-2-sulfinamide

Chemical Property of (r)-2-methyl-n-[(1e)-2,2,2-trifluoroethylidene]propane-2-sulfinamide

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (r)-2-methyl-n-[(1e)-2,2,2-trifluoroethylidene]propane-2-sulfinamide

There total 1 articles about (r)-2-methyl-n-[(1e)-2,2,2-trifluoroethylidene]propane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,2-Trifluoroacetaldehyde (75-90-1) + (R)-2-methylpropane-2-sulfinamide (196929-78-9) → (RS)-N-tert-butanesulfinyl-(3,3,3)-trifluoroacetaldimine (1219607-85-8,1219607-83-6)

Guidance literature:

With titanium(IV) tetraethanolate; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/ejoc.202000598

Reference yield: 86.0%

(RS)-N-tert-butanesulfinyl-(3,3,3)-trifluoroacetaldimine (1219607-85-8,1219607-83-6) + 1,1,1,3,3-pentafluoro-3-(phenylsulfonyl)propane-2,2-diol → C13H16F5NO3S2

Guidance literature:

(R_S)-N-tert-butanesulfinyl-(3,3,3)-trifluoroacetaldimine; 1,1,1,3,3-pentafluoro-3-(phenylsulfonyl)propane-2,2-diol; With lithium bromide; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere; Molecular sieve;

With triethylamine; In tetrahydrofuran; at -78 ℃; for 4h; Reagent/catalyst; Solvent; Temperature; diastereoselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1002/ejoc.202100350

Reference yield: 76.0%

(RS)-N-tert-butanesulfinyl-(3,3,3)-trifluoroacetaldimine (1219607-85-8,1219607-83-6) + C9H6BrF5O4S → C13H15BrF5NO3S2

Guidance literature:

(R_S)-N-tert-butanesulfinyl-(3,3,3)-trifluoroacetaldimine; C₉H₆BrF₅O₄S; With lithium bromide; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere; Molecular sieve;

With triethylamine; In tetrahydrofuran; at -78 ℃; for 4h; diastereoselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1002/ejoc.202100350

upstream raw materials:

2,2,2-Trifluoroacetaldehyde

(R)-2-methylpropane-2-sulfinamide