4,5-O-(1-Methylethylidene)-3,6-bis-O-(phenylMethyl)-1-O-(triphenylMethyl)-DL-Myo-inositol

Base Information

• Chemical Name: 4,5-O-(1-Methylethylidene)-3,6-bis-O-(phenylMethyl)-1-O-(triphenylMethyl)-DL-Myo-inositol
• CAS No.: 114218-25-6
• Molecular Formula: C₄₂H₄₂O₆
• Molecular Weight: 642.792
• Mol file: 114218-25-6.mol

Synonyms:4,5-O-(1-Methylethylidene)-3,6-bis-O-(phenylMethyl)-1-O-(triphenylMethyl)-DL-Myo-inositol;4,5-O-Isopropylidene-3,6-bis-O-(phenylMethyl)-1-O-(triphenylMethyl) DL-Myo-Inositol

Chemical Property of 4,5-O-(1-Methylethylidene)-3,6-bis-O-(phenylMethyl)-1-O-(triphenylMethyl)-DL-Myo-inositol

Chemical Property:

• Boiling Point: 729.4±60.0 °C(Predicted)
• PKA: 12.96±0.70(Predicted)
• PSA: 66.38000
• Density: 1.24±0.1 g/cm3(Predicted)
• LogP: 7.42910

Purity/Quality:

95% ^*data from raw suppliers

4,5-O-Isopropylidene-3,6-bis-O-(phenylmethyl)-1-O-(triphenylmethyl)DL-myo-Inositol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Inositol derivative.

Technology Process of 4,5-O-(1-Methylethylidene)-3,6-bis-O-(phenylMethyl)-1-O-(triphenylMethyl)-DL-Myo-inositol

There total 2 articles about 4,5-O-(1-Methylethylidene)-3,6-bis-O-(phenylMethyl)-1-O-(triphenylMethyl)-DL-Myo-inositol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(±)-1,4-di-O-benzyl-myo-inositol (35949-67-8,58769-24-7,58769-27-0,99782-78-2,111408-68-5,129706-81-6,141040-66-6) → (+/-)-1,4-di-O-benzyl-5,6-O-isopropylidene-3-O-trityl-myo-inositol (114218-25-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) toluene p-sulphonic acid monohydrate / 1.) DMSO, 20 deg C; 2.) DMSO, 10 min

2: 1.) triethylamine, pyridine; 2.) methanol / 1.) reflux, 8 h; 2.) 1 h

With pyridine; methanol; triethylamine; toluene-4-sulfonic acid;

DOI:10.1039/P19870001757

Reference yield:

trityl chloride (76-83-5) + (+/-)-1,4-di-O-benzyl-5,6-O-isopropylidine-myo-inositol (98906-25-3,114297-83-5,117307-15-0,142435-92-5,173828-64-3) → (+/-)-1,4-di-O-benzyl-5,6-O-isopropylidene-3-O-trityl-myo-inositol (114218-25-6)

Guidance literature:

With pyridine; methanol; triethylamine; Yield given. Multistep reaction; 1.) reflux, 8 h; 2.) 1 h;

DOI:10.1039/P19870001757

Reference yield:

(+/-)-1,4-di-O-benzyl-5,6-O-isopropylidene-3-O-trityl-myo-inositol (114218-25-6) → (±)-2,3,6-tri-O-benzyl-myo-inositol (98906-30-0,104873-76-9,111466-07-0,114297-88-0,114297-91-5,114419-08-8,115184-71-9,115509-75-6,115509-76-7,118354-54-4,118354-55-5,128163-34-8,129706-80-5,136521-84-1,149713-88-2,149713-95-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide

2: 1 M HCl, acetone / 1 h / Heating

With hydrogenchloride; sodium hydride; acetone; In N,N-dimethyl-formamide;

DOI:10.1039/P19870001757

upstream raw materials:

trityl chloride

(+/-)-1,4-di-O-benzyl-5,6-O-isopropylidine-myo-inositol

(±)-1,4-di-O-benzyl-myo-inositol

Downstream raw materials:

(+/-)-1,2,4-tri-O-benzyl-5,6-isopropylidene-3-O-trityl-myo-inositol

(±)-2,3,6-tri-O-benzyl-myo-inositol