1-(cyclopropylcarbonyl)-3-piperidinamine(SALTDATA: HCl)

Base Information

• Chemical Name: 1-(cyclopropylcarbonyl)-3-piperidinamine(SALTDATA: HCl)
• CAS No.: 1114596-39-2
• Molecular Formula: C₉H₁₆N₂O
• Molecular Weight: 168.239
• Hs Code.: 2933399090
• Mol file: 1114596-39-2.mol

Synonyms:1-(cyclopropylcarbonyl)-3-piperidinamine(SALTDATA: HCl)

Chemical Property of 1-(cyclopropylcarbonyl)-3-piperidinamine(SALTDATA: HCl)

Chemical Property:

• PSA: 46.33000
• LogP: 0.98430

Purity/Quality:

97% ^*data from raw suppliers

1-(Cyclopropylcarbonyl)piperidin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(cyclopropylcarbonyl)-3-piperidinamine(SALTDATA: HCl)

There total 2 articles about 1-(cyclopropylcarbonyl)-3-piperidinamine(SALTDATA: HCl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

t-butyl piperidin-3-ylcarbamate (184637-48-7,172603-05-3) → rac-(3-aminopiperidin-1-yl) (cyclopropyl)methanone (1114596-39-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C

1.2: 20 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

2.2: 0.17 h / 5 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.1c00868

Reference yield:

rac-tert-butyl (1-(cyclopropanecarbonyl)piperidin-3-yl)carbamate → rac-(3-aminopiperidin-1-yl) (cyclopropyl)methanone (1114596-39-2)

Guidance literature:

rac-tert-butyl (1-(cyclopropanecarbonyl)piperidin-3-yl)carbamate; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1h;

With potassium carbonate; In methanol; at 5 ℃; for 0.166667h;

DOI:10.1021/acs.jmedchem.1c00868

Reference yield: 81.0%

rac-(3-aminopiperidin-1-yl) (cyclopropyl)methanone (1114596-39-2) + (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-cyclohexylbutanoic acid (269078-73-1,269078-72-0) → (9H-fluoren-9-yl)methyl ((S)-4-cyclohexyl-1-((1-(cyclopropanecarbonyl)piperidin-3-yl)amino)-1-oxobutan-2-yl)carbamate

Guidance literature:

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-cyclohexylbutanoic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

rac-(3-aminopiperidin-1-yl) (cyclopropyl)methanone; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

DOI:10.1021/acs.jmedchem.1c00868

upstream raw materials:

t-butyl piperidin-3-ylcarbamate

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