(S)-1-(3-Methoxyphenyl)propanol

Base Information

• Chemical Name: (S)-1-(3-Methoxyphenyl)propanol
• CAS No.: 134677-28-4
• Molecular Formula: C10H14O2
• Molecular Weight: 166.22
• Mol file: 134677-28-4.mol

Synonyms:(S)-1-(3-Methoxyphenyl)propanol;(1S)-1-(3-Methoxyphenyl)-1-propanol

Chemical Property of (S)-1-(3-Methoxyphenyl)propanol

Chemical Property:

• PSA: 29.46000
• LogP: 2.13860

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-1-(3-Methoxyphenyl)propanol

There total 13 articles about (S)-1-(3-Methoxyphenyl)propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diethylzinc (557-20-0) + 3-methoxy-benzaldehyde (591-31-1) → (1S)-1-(3-methoxyphenyl)propan-1-ol (134677-28-4)

Guidance literature:

(1S)-1-(9-piperidylfluoren-9-yl)ethanol; In hexane; toluene; at 0 ℃; for 4h;

DOI:10.1055/s-2000-6229

Reference yield: 99.0%

→ (R)-1-(3-methoxyphenyl)-1-propanol + (1S)-1-(3-methoxyphenyl)propan-1-ol (134677-28-4)

Guidance literature:

With C₃₆H₂₈FeMnN₂O₃P⁽¹⁺⁾*Br^(1-); potassium carbonate; In ethanol; at 20 ℃; for 0.0833333h; Glovebox;

With hydrogen; In ethanol; at 50 ℃; for 16h; under 22502.3 Torr; Glovebox; Autoclave;

Reference yield: 98.0%

diethylzinc (557-20-0) + 3-methoxy-benzaldehyde (591-31-1) → (R)-1-(3-methoxyphenyl)-1-propanol + (1S)-1-(3-methoxyphenyl)propan-1-ol (134677-28-4)

Guidance literature:

diethylzinc; With N-(5,8-bismethoxymethoxy-2-methyl-1,2-dihydronaphthalen-1-yl)-4-methylbenzenesulfonate; In hexane; ethyl acetate; at 20 ℃; for 1h; Inert atmosphere;

3-methoxy-benzaldehyde; In hexane; ethyl acetate; at 30 ℃; for 24h; optical yield given as %ee;

DOI:10.1039/b902602a

upstream raw materials:

diethylzinc

3-methoxy-benzaldehyde

triethylaluminum

ethylmagnesium chloride

Downstream raw materials:

C₂₀H₂₆O₄Se₂

Refernces

• 1、 Satyanarayana, Tummanapalli,Kagan, Henri B.. "Asymmetric amplification by kinetic resolution using a racemic reagent: Example in amine acetylation". . p. 5785 - 5789. Retrieved 2006.
• 2、 Pathak, Kavita,Bhatt, Achyut P.,Abdi, Sayed H.R.,Kureshy, Rukhsana I.,Khan, Noor-ul H.,Ahmad, Irshad,Jasra, Raksh V.. "Enantioselective addition of diethylzinc to aldehydes using immobilized chiral BINOL-Ti complex on ordered mesoporous silicas". . p. 1506 - 1513. Retrieved 2006.
• 3、 -. "Tridentate nitrogen phosphine ligand containing arylamine NH as well as preparation method and application thereof". Paragraph 0095-0102; 0105-0109. . Retrieved 2021/06/26.
• 4、 Aydin, A. E.. "Enantioselective Addition of Diethylzinc to Aromatic Aldehydes Using Chiral Oxazoline-Based Ligands". . p. 1304 - 1312. Retrieved 2020/10/02.