Intermediate of Rolapitant

Base Information

Chemical Name:Intermediate of Rolapitant
CAS No.:552293-34-2
Molecular Formula:C₃₀H₂₇F₆NO₃
Molecular Weight:563.54
Hs Code.:

Synonyms:benzyl(2S)-2-({(1-R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-2-phenyl-3,4-dihydropyridine-1(2H)-carboxylate

Suppliers and Price of Intermediate of Rolapitant

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 6 raw suppliers

Chemical Property of Intermediate of Rolapitant

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of Intermediate of Rolapitant

There total 8 articles about Intermediate of Rolapitant which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: C₃₃H₃₅F₆NO₅

: 552293-34-2
benzyl (2S)-2-({(1-R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-2-phenyl-3,4-dihydropyridine-1(2h)-carboxylate

Guidance literature:: With toluene-4-sulfonic acid; In ethanol; for 4h; Reflux;

Reference yield: 70.0%

: C₃₃H₃₃F₆NO₅

: 552293-34-2
benzyl (2S)-2-({(1-R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-2-phenyl-3,4-dihydropyridine-1(2h)-carboxylate

Guidance literature:: C₃₃H₃₃F₆NO₅; With platinum(IV) oxide; hydrogen;

With hydrogenchloride; at 80 ℃;
DOI:10.1016/j.tetlet.2013.08.131

Reference yield:

: benzyl (2R,4S)-5-oxo-2,4-diphenyl-oxazolidine-3-carboxylate

: 552293-34-2
benzyl (2S)-2-({(1-R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-2-phenyl-3,4-dihydropyridine-1(2h)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide

2.1: lithium borohydride / 0 °C

3.1: potassium hexamethylsilazane / -78 - 20 °C

4.1: hydrogen; platinum(IV) oxide

4.2: 80 °C

With platinum(IV) oxide; lithium borohydride; hydrogen; potassium hexamethylsilazane; lithium diisopropyl amide; 3.1: |Wittig Olefination;
DOI:10.1016/j.tetlet.2013.08.131