3-(tert-butoxycarbonyl)-3-azabicyclo[4.1.0]heptane-1-carboxylic acid

Base Information

Chemical Name:3-(tert-butoxycarbonyl)-3-azabicyclo[4.1.0]heptane-1-carboxylic acid
CAS No.:1239421-67-0
Molecular Formula:C₁₂H₁₉NO₄
Molecular Weight:241.287
Hs Code.:
Mol file:1239421-67-0.mol

Synonyms:3-(tert-butoxycarbonyl)-3-azabicyclo[4.1.0]heptane-1-carboxylic acid

Suppliers and Price of 3-(tert-butoxycarbonyl)-3-azabicyclo[4.1.0]heptane-1-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 6 raw suppliers

Chemical Property of 3-(tert-butoxycarbonyl)-3-azabicyclo[4.1.0]heptane-1-carboxylic acid

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of 3-(tert-butoxycarbonyl)-3-azabicyclo[4.1.0]heptane-1-carboxylic acid

There total 7 articles about 3-(tert-butoxycarbonyl)-3-azabicyclo[4.1.0]heptane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1192688-49-5
3-tert-butyl 1-methyl 3-aza-bicyclo[4.1.0]heptane-1,3-dicarboxylate

: 1239421-67-0,1250993-15-7
3-(tert-butoxycarbonyl)-3-azabicyclo[4.1.0]heptane-1-carboxylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 3h; chemoselective reaction;
DOI:10.1016/j.tet.2010.05.006

Reference yield:

: C₁₂H₁₉NO₃

: 1239421-67-0,1250993-15-7
3-(tert-butoxycarbonyl)-3-azabicyclo[4.1.0]heptane-1-carboxylic acid

Guidance literature:: With sodium chlorite; disodium hydrogenphosphate; 2-methyl-but-2-ene; In water; acetone; for 24h;
DOI:10.1016/j.tetasy.2015.09.015

Reference yield:

: 309748-42-3
(3-Benzyl-3-aza-bicyclor[4.1.0]hept-1-yl)-methanol

: 1239421-67-0,1250993-15-7
3-(tert-butoxycarbonyl)-3-azabicyclo[4.1.0]heptane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 48 h / 50 °C / 52505.3 Torr / Inert atmosphere

2: Dess-Martin periodane / dichloromethane / Reflux

3: disodium hydrogenphosphate; 2-methyl-but-2-ene; sodium chlorite / water; acetone / 24 h

With sodium chlorite; disodium hydrogenphosphate; 2-methyl-but-2-ene; palladium 10% on activated carbon; hydrogen; Dess-Martin periodane; In methanol; dichloromethane; water; acetone;
DOI:10.1016/j.tetasy.2015.09.015