2-Chloro-5-methoxypyridine-3-boronic acid

Base Information

• Chemical Name: 2-Chloro-5-methoxypyridine-3-boronic acid
• CAS No.: 1072946-26-9
• Molecular Formula: C13H6ClN3O2
• Molecular Weight: 271.66
• Hs Code.: 2933399990
• Mol file: 1072946-26-9.mol

Synonyms:TIMTEC-BB SBB003039;2-AMINO-7-CHLORO-5-OXO-5H-(1)BENZOPYRANO-(2,3-B)-PYRIDINE-3-CARBONITRILE;2-AMINO-7-CHLORO-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBONITRILE;2-amino-7-chloro-5-oxo-5H-(1)benzopyrano-(2,3-B)P;2-(4-Methoxybenzyloxy)-5-(trifluoromethyl)pyridine;2-(N-Benzylamino)-5-chloro-3-fluoropyridine;N-Benzyl-5-chloro-3-fluoropyridin-2-amine;2,2'-Bipyridine-3,3'-dicarbonitrile

Chemical Property of 2-Chloro-5-methoxypyridine-3-boronic acid

Chemical Property:

• Melting Point: >300 °C(lit.)
• PSA: 62.58000
• LogP: -0.57660
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-5-methoxypyridine-3-boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-5-methoxypyridine-3-boronic acid

There total 3 articles about 2-Chloro-5-methoxypyridine-3-boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-5-methoxypyridin-3-ylboronic ester → (2-chloro-5-methoxypyridin-3-yl)boronic acid (1072946-26-9)

Guidance literature:

2-chloro-5-methoxypyridin-3-ylboronic ester; With sodium hydroxide; In tetrahydrofuran; hexane; water; at 22 ℃;

With hydrogenchloride; In water; pH=5;

DOI:10.1021/jm300184s

Reference yield:

3-bromo-2-chloro-5-methoxypyridine (1033202-44-6) → (2-chloro-5-methoxypyridin-3-yl)boronic acid (1072946-26-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium; Triisopropyl borate / tetrahydrofuran; hexane / 2 h / -78 - 22 °C / Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran; hexane; water / 22 °C

2.2: pH 5

With n-butyllithium; Triisopropyl borate; sodium hydroxide; In tetrahydrofuran; hexane; water;

DOI:10.1021/jm300184s

Reference yield:

5-bromo-6-chloropyridin-3-ol (130115-85-4) → (2-chloro-5-methoxypyridin-3-yl)boronic acid (1072946-26-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 22 - 45 °C

2.1: n-butyllithium; Triisopropyl borate / tetrahydrofuran; hexane / 2 h / -78 - 22 °C / Inert atmosphere

3.1: sodium hydroxide / tetrahydrofuran; hexane; water / 22 °C

3.2: pH 5

With n-butyllithium; Triisopropyl borate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm300184s

upstream raw materials:

3-bromo-2-chloro-5-methoxypyridine

5-bromo-6-chloropyridin-3-ol

Downstream raw materials:

trans-[4-(2-chloroacetylamino)cyclohexyl]carbamic tert-butyl ester

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