2-(ChloroMethyl)-6-Methoxypyridine hydrochloride

Base Information

• Chemical Name: 2-(ChloroMethyl)-6-Methoxypyridine hydrochloride
• CAS No.: 864264-99-3
• Molecular Formula: C₇H₈ClNO*ClH
• Molecular Weight: 194.061
• Hs Code.: 2933399090
• Mol file: 864264-99-3.mol

Synonyms:2-(ChloroMethyl)-6-Methoxypyridine hydrochloride

Chemical Property of 2-(ChloroMethyl)-6-Methoxypyridine hydrochloride

Chemical Property:

• PSA: 22.12000
• LogP: 2.63100
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

2-(Chloromethyl)-6-methoxypyridinehydrochloride >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(ChloroMethyl)-6-Methoxypyridine hydrochloride

There total 4 articles about 2-(ChloroMethyl)-6-Methoxypyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(6-methoxy-pyridin-2-yl)-methanol (63071-12-5) → 2-(chloromethyl)-6-methoxypyridine hydrochloride (864264-99-3)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere; Glovebox; Schlenk technique;

DOI:10.1021/jacs.9b04729

Reference yield:

6-Hydroxypicolinic acid (19621-92-2) → 2-(chloromethyl)-6-methoxypyridine hydrochloride (864264-99-3)

Guidance literature:

Multi-step reaction with 3 steps

1: silver carbonate / chloroform / Inert atmosphere; Glovebox; Schlenk technique; Darkness; Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere; Glovebox; Schlenk technique

3: thionyl chloride / dichloromethane / 1 h / 0 °C / Inert atmosphere; Glovebox; Schlenk technique

With lithium aluminium tetrahydride; thionyl chloride; silver carbonate; In tetrahydrofuran; dichloromethane; chloroform;

DOI:10.1021/jacs.9b04729

Reference yield:

6-methoxy-pyridine-2-carboxylic acid methyl ester (26256-72-4) → 2-(chloromethyl)-6-methoxypyridine hydrochloride (864264-99-3)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere; Glovebox; Schlenk technique

2: thionyl chloride / dichloromethane / 1 h / 0 °C / Inert atmosphere; Glovebox; Schlenk technique

With lithium aluminium tetrahydride; thionyl chloride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jacs.9b04729

upstream raw materials:

6-Hydroxypicolinic acid

6-methoxy-pyridine-2-carboxylic acid methyl ester

(6-methoxy-pyridin-2-yl)-methanol

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