Ethyl 3-Methyl-a,g-dioxo-benzenebutanoate

Base Information

• Chemical Name: Ethyl 3-Methyl-a,g-dioxo-benzenebutanoate
• CAS No.: 741286-41-9
• Molecular Formula: C13H14O4
• Molecular Weight: 234.252
• Mol file: 741286-41-9.mol

Synonyms:Ethyl 3-Methyl-a,g-dioxo-benzenebutanoate

Chemical Property of Ethyl 3-Methyl-a,g-dioxo-benzenebutanoate

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 3-Methyl-a,g-dioxo-benzenebutanoate

There total 4 articles about Ethyl 3-Methyl-a,g-dioxo-benzenebutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

oxalic acid diethyl ester (95-92-1) + 3-Methylacetophenone (585-74-0) → ethyl 2,4-dioxo-4-m-tolylbutanoate (741286-41-9)

Guidance literature:

oxalic acid diethyl ester; With sodium methylate; In diethyl ether; at 20 ℃; Inert atmosphere;

3-Methylacetophenone; In diethyl ether; at 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2010.07.004

Reference yield: 81.0%

→ ethyl 2,4-dioxo-4-m-tolylbutanoate (741286-41-9)

Guidance literature:

Reference yield:

m-tolyl aldehyde (620-23-5) → ethyl 2,4-dioxo-4-m-tolylbutanoate (741286-41-9)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 3.17 h / 0 - 20 °C / Inert atmosphere

2: silica gel; manganese(IV) oxide / acetonitrile / 8 h / 70 °C / Molecular sieve

3: sodium hydride / toluene / 2 h / 90 °C

With manganese(IV) oxide; silica gel; sodium hydride; In tetrahydrofuran; toluene; acetonitrile;

DOI:10.1016/j.ejmech.2018.09.053

upstream raw materials:

oxalic acid diethyl ester

3-Methylacetophenone

m-tolyl aldehyde

1-(m-methylphenyl)ethanol

Downstream raw materials:

ethyl 3-(m-tolyl)-1H-pyrazole-5-carboxylate

5-(3-methylphenyl)isoxazole-3-carboxylic acid