tert-butyl octahydropyrrolo[3,4-b]morpholine-6-carboxylate

Base Information

Chemical Name:tert-butyl octahydropyrrolo[3,4-b]morpholine-6-carboxylate
CAS No.:1360364-21-1
Molecular Formula:C₁₁H₂₀N₂O₃
Molecular Weight:228.291
Hs Code.:
Mol file:1360364-21-1.mol

Synonyms:tert-butyl octahydropyrrolo[3,4-b]morpholine-6-carboxylate;tert-Butyl hexahydropyrrolo[3,4-b][1,4]oxazine-6(2H)-carboxylate;Pyrrolo[3,4-b]-1,4-oxazine-6(2H)-carboxylic acid, hexahydro-, 1,1-dimethylethyl ester

Suppliers and Price of tert-butyl octahydropyrrolo[3,4-b]morpholine-6-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
tert-Butylhexahydropyrrolo[3,4-b][1,4]oxazine-6(2H)-carboxylate
5mg
$ 65.00

Crysdot
tert-Butylhexahydropyrrolo[3,4-b][1,4]oxazine-6(2H)-carboxylate 95+%
250mg
$ 411.00

Crysdot
tert-Butylhexahydropyrrolo[3,4-b][1,4]oxazine-6(2H)-carboxylate 95+%
1g
$ 1028.00

Chemenu
tert-Butylhexahydropyrrolo[3,4-b][1,4]oxazine-6(2H)-carboxylate 95%
1g
$ 961.00

Alichem
tert-Butylhexahydropyrrolo[3,4-b][1,4]oxazine-6(2H)-carboxylate
250mg
$ 402.78

Total 13 raw suppliers

Chemical Property of tert-butyl octahydropyrrolo[3,4-b]morpholine-6-carboxylate

Chemical Property:

Boiling Point:324.9±32.0 °C(Predicted)
PKA:8.26±0.20(Predicted)
Density:1.108±0.06 g/cm3(Predicted)
Storage Temp.:2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butylhexahydropyrrolo[3,4-b][1,4]oxazine-6(2H)-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl octahydropyrrolo[3,4-b]morpholine-6-carboxylate

There total 5 articles about tert-butyl octahydropyrrolo[3,4-b]morpholine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1358783-18-2
hexahydro-4-benzyl-pyrrolo[3,4-b]-1,4-oxazin-6 (2H)-carboxylic acid tert-butyl ester

: 1360364-21-1,138026-93-4
tert-butyl 3,4,4a,5,7,7a-hexahydro-2H-pyrrolo[3,4-b][1,4]oxazine-6-carboxylate

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol;

Reference yield:

: 73286-70-1
N-(tert-butoxycarbonyl)-3-pyrroline

: 1360364-21-1,138026-93-4
tert-butyl 3,4,4a,5,7,7a-hexahydro-2H-pyrrolo[3,4-b][1,4]oxazine-6-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / 18 h

2.1: triethylamine; dmap / toluene / 1 h / 0 °C

3.1: para-xylene / 7 h / Reflux

3.2: 1.5 h / 0 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol / 16 h

With dmap; N-Bromosuccinimide; palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; para-xylene; toluene;

Reference yield:

: 1358783-14-8
3-bromo-4-(2-hydroxyethoxy)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1360364-21-1,138026-93-4
tert-butyl 3,4,4a,5,7,7a-hexahydro-2H-pyrrolo[3,4-b][1,4]oxazine-6-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; dmap / toluene / 1 h / 0 °C

2.1: para-xylene / 7 h / Reflux

2.2: 1.5 h / 0 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 16 h

With dmap; palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; para-xylene; toluene;