Chemical Property of STK393606
Chemical Property:
- Solubility.:≤12mg/ml in DMSO;14mg/ml in dimethyl formamide
- Purity/Quality:
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99% *data from raw suppliers
2-(((6-Bromo-3H-imidazo[4,5-b]pyridin-2-yl)thio)methyl)benzonitrile 97% *data from reagent suppliers
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Useful:
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Description
15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH) is a key enzyme involved in the inactivation of PGs and related eiscosanoids. It functions by catalyzing the oxidation of primary PGs to their 15-keto metabolites. Two types of 15-hydroxy PGDH have been identified: type-I is NAD+-dependent primarily using eicosanoids as substrates, while type-II uses either NAD+ or NADP+ as cofactors and bears broader substrate specificity. STK393606 is a competitive inhibitor of NAD+-dependent type-I 15-hydroxy PGDH with an IC50 value of 26.4 nM and a Ki value of 5 nM. It demonstrates selectivity for 15-hydroxy PGDH when profiled across a panel of related dehydrogenase or reductase enzymes.
