2-P-TOLYL-BENZO[D]IMIDAZO[2,1-B]THIAZOLE

Base Information

• Chemical Name: 2-P-TOLYL-BENZO[D]IMIDAZO[2,1-B]THIAZOLE
• CAS No.: 38956-27-3
• Molecular Formula: C16H12N2S
• Molecular Weight: 264.351
• Mol file: 38956-27-3.mol

Synonyms:2-P-TOLYL-BENZO[D]IMIDAZO[2,1-B]THIAZOLE

Chemical Property of 2-P-TOLYL-BENZO[D]IMIDAZO[2,1-B]THIAZOLE

Chemical Property:

• PSA: 45.54000
• LogP: 4.52440

Purity/Quality:

98%min ^*data from raw suppliers

2-(p-Tolyl)benzo[d]imidazo[2,1-b]thiazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-P-TOLYL-BENZO[D]IMIDAZO[2,1-B]THIAZOLE

There total 6 articles about 2-P-TOLYL-BENZO[D]IMIDAZO[2,1-B]THIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-amino-benzthiazole (136-95-8,102337-98-4,84293-42-5) + 4-(bromoacetyl)toluene (619-41-0) → 2-(4-methylphenyl)imidazo[2,1-b]benzothiazole (38956-27-3)

Guidance literature:

In water; isopropyl alcohol; at 100 ℃; under 11251.1 Torr; Microwave irradiation; Green chemistry;

DOI:10.1039/c9ra08929b

Reference yield: 94.0%

2-amino-benzthiazole (136-95-8,102337-98-4,84293-42-5) + nitromethane (75-52-5) + 4-methyl-benzaldehyde (104-87-0) → 2-(4-methylphenyl)imidazo[2,1-b]benzothiazole (38956-27-3)

Guidance literature:

With iron(III) chloride; In neat (no solvent); at 80 ℃; for 6h;

DOI:10.1039/c6ra24183b

Reference yield: 80.0%

2-amino-benzthiazole (136-95-8,102337-98-4,84293-42-5) + para-methylacetophenone (122-00-9) → 2-(4-methylphenyl)imidazo[2,1-b]benzothiazole (38956-27-3)

Guidance literature:

With iron(III) chloride; zinc(II) iodide; In 1,2-dichloro-benzene; at 110 ℃; for 15h;

DOI:10.1021/ol5028893

upstream raw materials:

2-amino-benzthiazole

4-(bromoacetyl)toluene

para-methylacetophenone

nitromethane

Downstream raw materials:

Dimethyl-(2-p-tolyl-benzo[d]imidazo[2,1-b]thiazol-3-ylmethyl)-amine

Refernces

• 1、 Mukku, Narasimharao,Maiti, Barnali. "On water catalyst-free synthesis of benzo[: D] imidazo[2,1- b] thiazoles and novel N -alkylated 2-aminobenzo [d] oxazoles under microwave irradiation". . p. 770 - 778. Retrieved 2020/01/23.
• 2、 Mishra, Subhajit,Monir, Kamarul,Mitra, Shubhanjan,Hajra, Alakananda. "FeCl3/ZnI2-catalyzed synthesis of benzo[D]imidazo[2,1-b]thiazole through aerobic oxidative cyclization between 2-aminobenzothiazole and ketone". supporting information. p. 6084 - 6087. Retrieved 2015/01/09.