3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxy-

Base Information

Chemical Name:3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxy-
CAS No.:214470-66-3
Molecular Formula:C₁₄H₁₃ClN₂O₃
Molecular Weight:292.722
Hs Code.:
Mol file:214470-66-3.mol

Synonyms:3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxy-;7-(3-chloropropoxy)-4-hydroxy-6-methoxyquinoline-3-carbonitrile;7-(3-Chloropropoxy)-4-hydroxy-6-methoxy-3-quinolinecarbonitrile

Suppliers and Price of 3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxy-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 20 raw suppliers

Chemical Property of 3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxy-

Chemical Property:

Vapor Pressure:7.04E-11mmHg at 25°C
Boiling Point:506.4°C at 760 mmHg
PKA:1.02±0.50(Predicted)
Flash Point:260.1°C
PSA：75.11000
Density:1.37g/cm³
LogP:2.41608

Purity/Quality:: 98%,99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 7-(3-Chloropropoxy)-4-hydroxy-6-methoxyquinoline-3-carbonitrile is a key intermediate in the synthesis of the anticancer medication Bosutinib(B676095 ).

Technology Process of 3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxy-

There total 13 articles about 3-Quinolinecarbonitrile, 7-(3-chloropropoxy)-4-hydroxy-6-Methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 2-(4-(3-chloropropoxy)-5-methoxy-2-nitrobenzoyl)-3-(dimethylamino)acrylonitrile

: 214470-66-3,1057670-58-2
7-(3-chloropropoxy)-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile

Guidance literature:: With hydrogen; nickel; In tetrahydrofuran; at 20 ℃; for 6h;
DOI:10.1080/00304948.2015.1025014

Reference yield: 71.0%

: 1637593-19-1
3-(2-amino-4-(3-chloropropoxy)-5-methoxyphenyl)-3-oxopropanenitrile

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 214470-66-3,1057670-58-2
7-(3-chloropropoxy)-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 2h; Green chemistry;
DOI:10.3987/COM-14-13023

Reference yield:

: 20428-58-4
α-lithioacetonitrile

: (E)-methyl 4-(3-chloropropoxy)-2-[(dimethylamino)methyleneamino]-5-methoxybenzoate

: 214470-66-3,1057670-58-2
7-(3-chloropropoxy)-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile

Guidance literature:: α-lithioacetonitrile; (E)-methyl 4-(3-chloropropoxy)-2-[(dimethylamino)methyleneamino]-5-methoxybenzoate; In tetrahydrofuran; at -78 ℃;

With acetic acid; at 20 ℃;
DOI:10.1016/S0960-894X(00)00580-1