4,4'-DiaMino-2,2'-difluorobiphenyl

Base Information

• Chemical Name: 4,4'-DiaMino-2,2'-difluorobiphenyl
• CAS No.: 316-64-3
• Molecular Formula: C12H10F2N2
• Molecular Weight: 220.222
• Mol file: 316-64-3.mol

Synonyms:4,4'-DiaMino-2,2'-difluorobiphenyl

Chemical Property of 4,4'-DiaMino-2,2'-difluorobiphenyl

Chemical Property:

• Melting Point: 115-116 °C
• Boiling Point: 346.9±37.0 °C(Predicted)
• PKA: 3.73±0.10(Predicted)
• PSA: 52.04000
• Density: 1.313±0.06 g/cm3(Predicted)
• LogP: 3.95860
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

4,4''-Diamino-2,2’-difluorobiphenyl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4,4''-Diamino-2,2’-difluorobiphenyl is used as a reactant in the preparation of benzidine and diaminofluorene prolinamide derivatives as hepatitis C virus NS5A inhibitors.

Technology Process of 4,4'-DiaMino-2,2'-difluorobiphenyl

There total 5 articles about 4,4'-DiaMino-2,2'-difluorobiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

→ 4,4'-diamino-2,2'-difluorobiphenyl (316-64-3)

Guidance literature:

With 3% Pd/C; hydrazine; In ethanol; Heating;

Reference yield:

3-fluoro-1-nitrobenzene (402-67-5) → 4,4'-diamino-2,2'-difluorobiphenyl (316-64-3)

Guidance literature:

With zinc; in alkal.Loesung und anschliessend mit Zinn und wss.HCl;

DOI:10.1021/ja01117a050

Reference yield:

1,2-bis(3-fluorophenyl)hydrazine (331-20-4) → 4,4'-diamino-2,2'-difluorobiphenyl (316-64-3)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

3-fluoro-1-nitrobenzene

1,2-bis(3-fluorophenyl)hydrazine

1,2-bis(3-fluorophenyl)diazene oxide

(E)-1,2-bis(3-fluorophenyl)diazene