2-(Benzyloxy)benzohydrazide

Base Information

• Chemical Name: 2-(Benzyloxy)benzohydrazide
• CAS No.: 380335-36-4
• Molecular Formula: C14H14N2O2
• Molecular Weight: 242.277
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID80359068
• Wikidata: Q82140071
• ChEMBL ID: CHEMBL1587693
• Mol file: 380335-36-4.mol

Synonyms:2-(benzyloxy)benzohydrazide;380335-36-4;2-phenylmethoxybenzohydrazide;2-Benzyloxy-benzoic acid hydrazide;Oprea1_547712;CBDivE_004110;MLS000769194;SCHEMBL6748166;CHEMBL1587693;DTXSID80359068;HMS2782J08;BBL023345;MFCD00553734;STL065422;AKOS000319458;SB86176;935766;SMR000433928;VS-07398;CS-0286871;A913054;SR-01000031795;A1-02182;SR-01000031795-1;Z56820878

Chemical Property of 2-(Benzyloxy)benzohydrazide

Chemical Property:

• PSA: 64.35000
• LogP: 2.96030
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 242.105527694
• Heavy Atom Count: 18
• Complexity: 265

Purity/Quality:

98%min ^*data from raw suppliers

2-(Benzyloxy)benzohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC=CC=C2C(=O)NN

Technology Process of 2-(Benzyloxy)benzohydrazide

There total 5 articles about 2-(Benzyloxy)benzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-(benzyloxy)benzoate (55142-16-0) → 2-benzyloxybenzoic acid hyrdrazide (380335-36-4)

Guidance literature:

With hydrazine hydrate; In methanol; at 20 ℃; for 5h;

DOI:10.1016/j.bmcl.2005.02.014

Reference yield:

benzyl chloride (100-44-7) → 2-benzyloxybenzoic acid hyrdrazide (380335-36-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / methanol; water / 6 h / 20 °C

2: hydrazine hydrate / methanol / 5 h / 20 °C

With hydrazine hydrate; potassium hydroxide; In methanol; water;

DOI:10.1111/j.1747-0285.2010.01066.x

Reference yield:

methyl salicylate (119-36-8,8024-54-2) → 2-benzyloxybenzoic acid hyrdrazide (380335-36-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / methanol; water / 6 h / 20 °C

2: hydrazine hydrate / methanol / 5 h / 20 °C

With hydrazine hydrate; potassium hydroxide; In methanol; water;

DOI:10.1111/j.1747-0285.2010.01066.x

upstream raw materials:

methyl 2-(benzyloxy)benzoate

benzyl chloride

methyl salicylate

Downstream raw materials:

C₂₃H₁₉N₅O₃

C₂₃H₁₈N₆O₅

C₂₃H₁₉N₅O₄

C₂₄H₂₁N₅O₃

Refernces

• 1、 Radwan, Awwad A.,Al-Mohanna,Alanazi, Fares K.,Manogaran,Al-Dhfyan, Abdullah. "Target β-catenin/CD44/Nanog axis in colon cancer cells by certain N′-(2-oxoindolin-3-ylidene)-2-(benzyloxy)benzohydrazides". . p. 1664 - 1670. Retrieved 2016/12/22.
• 2、 Rajak, Harish,Singour, Pradeep,Kharya, Murli Dhar,Mishra, Pradeep. "A Novel Series of 2,5-Disubstituted 1,3,4-oxadiazoles: Synthesis and SAR Study for their Anticonvulsant Activity". experimental part. p. 152 - 158. Retrieved 2012/01/06.