2-Butyl-4-chloroquinoline

Base Information

• Chemical Name: 2-Butyl-4-chloroquinoline
• CAS No.: 144624-27-1
• Molecular Formula: C₁₃H₁₄ClN
• Molecular Weight: 219.714
• Hs Code.: 2933499090
• Mol file: 144624-27-1.mol

Synonyms:2-Butyl-4-chloroquinoline

Chemical Property of 2-Butyl-4-chloroquinoline

Chemical Property:

• PSA: 12.89000
• LogP: 4.23080

Purity/Quality:

98.5% ^*data from raw suppliers

2-Butyl-4-chloroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Butyl-4-chloroquinoline

There total 8 articles about 2-Butyl-4-chloroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-chloroquinoline (611-35-8) + butylboronic acid (4426-47-5) → 2-n-butyl-4-chloroquinoline (144624-27-1)

Guidance literature:

With tris(2,2'-bipyridyl)ruthenium dichloride; 1-acetoxy-1,2-benziodoxol-3-one; at 30 ℃; for 24h; Reagent/catalyst; Temperature; Catalytic behavior; Inert atmosphere; Irradiation;

DOI:10.1039/c6sc02653b

Reference yield: 76.0%

4-chloroquinoline (611-35-8) + n-butyllithium (109-72-8,29786-93-4) → 2-n-butyl-4-chloroquinoline (144624-27-1)

Guidance literature:

4-chloroquinoline; n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 4h;

With ammonium cerium(IV) nitrate; In water; acetone; for 0.5h;

DOI:10.1021/jo034758n

Reference yield: 65.0%

4-chloroquinoline (611-35-8) → 2-n-butyl-4-chloroquinoline (144624-27-1)

Guidance literature:

4-chloroquinoline; nBuX (X=halide); With n-butyllithium; In tetrahydrofuran; at -20 - 20 ℃;

With sodium hydroxide; iodine; at 20 ℃;

DOI:10.1016/S0960-894X(02)00470-5

upstream raw materials:

n-butyllithium

4-Chloroquinoline N-oxide

4-chloroquinoline

2-(n-butyl)-1H-4-quinolone

Refernces

• 1、 Wolf, Christian,Lerebours, Rachel. "Use of highly active palladium-phosphinous acid catalysts in Stille, Heck, amination, and thiation reactions of chloroquinolines". . p. 7077 - 7084. Retrieved 2007/10/03.
• 2、 Tagawa, Yoshinobu,Nomura, Manami,Yamashita, Hiroyuki,Goto, Yoshinobu,Hamana, Masatomo. "Reaction of quinoline N-oxides with alkyl- and aryllithiums in the presence of oxidant". . p. 2385 - 2397. Retrieved 2007/10/03.