4-BroMo-2-propoxybenzaldehyde

Base Information

• Chemical Name: 4-BroMo-2-propoxybenzaldehyde
• CAS No.: 1094555-01-7
• Molecular Formula: C10H11BrO2
• Molecular Weight: 243.1
• Hs Code.: 2913000090
• Mol file: 1094555-01-7.mol

Synonyms:4-BroMo-2-propoxybenzaldehyde

Chemical Property of 4-BroMo-2-propoxybenzaldehyde

Chemical Property:

• PSA: 26.30000
• LogP: 3.05040
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Bromo-2-propoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Bromo-2-propoxybenzaldehyde is a building block used in the synthesis of pharmaceuticals.

Technology Process of 4-BroMo-2-propoxybenzaldehyde

There total 2 articles about 4-BroMo-2-propoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-bromosalicylaldehyde (22532-62-3) + propyl bromide (106-94-5) → 4-bromo-2-propoxybenzaldehyde (1094555-01-7)

Guidance literature:

4-bromosalicylaldehyde; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;

propyl bromide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 - 60 ℃;

Reference yield: 95.0%

→ 4-bromo-2-propoxybenzaldehyde (1094555-01-7)

Guidance literature:

With potassium carbonate; In acetonitrile; at 50 ℃; for 5h;

Reference yield: 99.0%

4-bromo-2-propoxybenzaldehyde (1094555-01-7) → [4-bromo-2-(propyloxy)phenyl]methanol (1094510-28-7)

Guidance literature:

With methanol; sodium tetrahydroborate; at 20 ℃;

upstream raw materials:

4-bromosalicylaldehyde

propyl bromide

Downstream raw materials:

[4-bromo-2-(propyloxy)phenyl]methanol

Refernces

• 1、 -. "Boron Containing PDE4 Inhibitors". Paragraph 0647-0648; 0755-0756. . Retrieved 2020/04/29.
• 2、 -. "PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE". Page/Page column 35. . Retrieved 2010/04/03.