phenyldi-p-tolylphosphine oxide

Base Information

• Chemical Name: phenyldi-p-tolylphosphine oxide
• CAS No.: 18957-70-5
• Molecular Formula: C20H19OP
• Molecular Weight: 306.344
• Mol file: 18957-70-5.mol

Synonyms:phenyldi-p-tolylphosphine oxide

Chemical Property of phenyldi-p-tolylphosphine oxide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of phenyldi-p-tolylphosphine oxide

There total 30 articles about phenyldi-p-tolylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

di(p-tolyl)phosphine oxide (2409-61-2) + phenylboronic acid (98-80-6) → (phenyl)di(4-methylphenyl)phosphine oxide (18957-70-5)

Guidance literature:

With pyridine; potassium carbonate; nickel dibromide; In 1,2-dichloro-ethane; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol402672e

Reference yield: 96.0%

S-(4-methylphenyl) thiobenzoate (10371-42-3) + di(p-tolyl)phosphine oxide (2409-61-2) → (phenyl)di(4-methylphenyl)phosphine oxide (18957-70-5)

Guidance literature:

With bis(diphenylphosphino)propanepalladium(II) dichloride; sodium hydrogencarbonate; at 130 ℃; for 1h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.joc.0c01557

Reference yield: 93.0%

di(p-tolyl)phosphine oxide (2409-61-2) + Diphenyliodonium triflate (66003-76-7) → (phenyl)di(4-methylphenyl)phosphine oxide (18957-70-5)

Guidance literature:

With triethylamine; copper(l) chloride; In dichloromethane; at 20 ℃; for 0.166667h; Schlenk technique;

DOI:10.1021/jo4012199

upstream raw materials:

P,P-dichlorophenylphosphine oxide

para-methylphenylmagnesium bromide

tri(4-methylphenyl)phosphine oxide

phenyllithium

Downstream raw materials:

(phenyl)di(4-methylphenyl)phosphine

Refernces

• 1、 Hou, Hong,Zhou, Bing,Wang, Jiawei,Sun, Duhao,Yu, Huaguang,Chen, Xiaoyun,Han, Ying,Shi, Yaocheng,Yan, Chaoguo,Zhu, Shaoqun. "Visible-light-induced ligand to metal charge transfer excitation enabled phosphorylation of aryl halides". supporting information. p. 5702 - 5705. Retrieved 2021/06/16.
• 2、 Li, Chun Jing. "Aryltrimethylammonium Tetrafluoroborates in Nickel-Catalyzed C–P Bond-Forming Reactions". . p. 954 - 960. Retrieved 2021/07/22.