1-AZETIDINEACETIC ACID, 3-[[(1Z)-3-METHOXY-1-METHYL-3-OXO-1-PROPENYL]AMINO]-2-[(1E)-2-(2-METHOXYPHENYL)ETHENYL]-4-OXO-METHYL ESTER

Base Information

Chemical Name:1-AZETIDINEACETIC ACID, 3-[[(1Z)-3-METHOXY-1-METHYL-3-OXO-1-PROPENYL]AMINO]-2-[(1E)-2-(2-METHOXYPHENYL)ETHENYL]-4-OXO-METHYL ESTER
CAS No.:321870-36-4
Molecular Formula:C₂₀H₂₄N₂O₆
Molecular Weight:388.42
Hs Code.:
Mol file:321870-36-4.mol

Synonyms:1-AZETIDINEACETIC ACID, 3-[[(1Z)-3-METHOXY-1-METHYL-3-OXO-1-PROPENYL]AMINO]-2-[(1E)-2-(2-METHOXYPHENYL)ETHENYL]-4-OXO-METHYL ESTER

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Chemical Property of 1-AZETIDINEACETIC ACID, 3-[[(1Z)-3-METHOXY-1-METHYL-3-OXO-1-PROPENYL]AMINO]-2-[(1E)-2-(2-METHOXYPHENYL)ETHENYL]-4-OXO-METHYL ESTER

Chemical Property:

Boiling Point:577.7±50.0 °C(Predicted)
PKA:1.31±0.70(Predicted)
PSA：94.17000
Density:1.25±0.1 g/cm3(Predicted)
LogP:1.45600

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of 1-AZETIDINEACETIC ACID, 3-[[(1Z)-3-METHOXY-1-METHYL-3-OXO-1-PROPENYL]AMINO]-2-[(1E)-2-(2-METHOXYPHENYL)ETHENYL]-4-OXO-METHYL ESTER

There total 2 articles about 1-AZETIDINEACETIC ACID, 3-[[(1Z)-3-METHOXY-1-METHYL-3-OXO-1-PROPENYL]AMINO]-2-[(1E)-2-(2-METHOXYPHENYL)ETHENYL]-4-OXO-METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(E)-3-(2-Methoxy-phenyl)-prop-2-en-(E)-ylideneamino]-acetic acid methyl ester

: Sodium; ((Z)-2-methoxycarbonyl-1-methyl-vinylamino)-acetate

: 321870-36-4
(Z)-3-{(2S,3R)-1-Methoxycarbonylmethyl-2-[(E)-2-(2-methoxy-phenyl)-vinyl]-4-oxo-azetidin-3-ylamino}-but-2-enoic acid methyl ester

Guidance literature:: With propylphosphonic anhydride; triethylamine; In dichloromethane; at 0 - 3 ℃; for 4h;
DOI:10.1080/00397910008087001

Reference yield:

: 60125-24-8
(E)-3-(2-methoxyphenyl)propenal

: 321870-36-4
(Z)-3-{(2S,3R)-1-Methoxycarbonylmethyl-2-[(E)-2-(2-methoxy-phenyl)-vinyl]-4-oxo-azetidin-3-ylamino}-but-2-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: SiO₂ / CH₂Cl₂ / 2.75 h / 0 - 3 °C

2: propane phosphonic acid anhydride; Et₃N / CH₂Cl₂ / 4 h / 0 - 3 °C

With propylphosphonic anhydride; silica gel; triethylamine; In dichloromethane; 1: Condensation / 2: Cycloaddition;
DOI:10.1080/00397910008087001