Ethyl 2-(tert-butoxycarbonylaMino)-4,5,6,7-tetrahydrobenzo[d]thiazole-4-carboxylate

Base Information

• Chemical Name: Ethyl 2-(tert-butoxycarbonylaMino)-4,5,6,7-tetrahydrobenzo[d]thiazole-4-carboxylate
• CAS No.: 1369897-34-6
• Molecular Formula: C15H22N2O4S
• Molecular Weight: 326.41118
• Hs Code.: 2934200090
• Mol file: 1369897-34-6.mol

Synonyms:Ethyl 2-(tert-butoxycarbonylaMino)-4,5,6,7-tetrahydrobenzo[d]thiazole-4-carboxylate

Chemical Property of Ethyl 2-(tert-butoxycarbonylaMino)-4,5,6,7-tetrahydrobenzo[d]thiazole-4-carboxylate

Chemical Property:

• PSA: 109.25000
• LogP: 3.48670
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-tert-Butoxycarbonylamino-4,5,6,7-tetrahydro-benzothiazole-4-carboxylicAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2-(tert-butoxycarbonylaMino)-4,5,6,7-tetrahydrobenzo[d]thiazole-4-carboxylate

There total 3 articles about Ethyl 2-(tert-butoxycarbonylaMino)-4,5,6,7-tetrahydrobenzo[d]thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

di-tert-butyl dicarbonate (24424-99-5) + ethyl 2-amino-4,5,6,7-tetrahydrobenzo[d]thiazole-4-carboxylate (76263-11-1) → ethyl 2-((tert-butoxycarbonyl)amino)-4,5,6,7-tetrahydrobenzo[d]thiazole-4-carboxylate (1369897-34-6)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 25 ℃; Inert atmosphere;

DOI:10.1021/jm4017224

Reference yield:

ethyl 3-bromo-2-oxocyclohexanecarboxylate (30132-23-1) → ethyl 2-((tert-butoxycarbonyl)amino)-4,5,6,7-tetrahydrobenzo[d]thiazole-4-carboxylate (1369897-34-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / Inert atmosphere; Reflux

2: triethylamine; dmap / dichloromethane / 25 °C / Inert atmosphere

With dmap; triethylamine; In ethanol; dichloromethane;

DOI:10.1021/jm4017224

Reference yield:

ethyl 2-oxocyclohexane carboxylate (1655-07-8) → ethyl 2-((tert-butoxycarbonyl)amino)-4,5,6,7-tetrahydrobenzo[d]thiazole-4-carboxylate (1369897-34-6)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine / chloroform / 0.5 h / 0 °C / Inert atmosphere

2: ethanol / Inert atmosphere; Reflux

3: triethylamine; dmap / dichloromethane / 25 °C / Inert atmosphere

With dmap; bromine; triethylamine; In ethanol; dichloromethane; chloroform;

DOI:10.1021/jm4017224

upstream raw materials:

ethyl 3-bromo-2-oxocyclohexanecarboxylate

di-tert-butyl dicarbonate

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[d]thiazole-4-carboxylate

ethyl 2-oxocyclohexane carboxylate

Downstream raw materials:

(R)-2-amino-N-(4-(((2S,5R)-5-((R)-hydroxy(phenyl)methyl)pyrrolidin-2-yl)methyl)phenyl)-4,5,6,7-tetrahydrobenzo[d]thiazole-4-carboxamide

C₂₆H₃₀N₄O₂S

C₃₆H₄₆N₄O₆S

C₃₆H₄₆N₄O₆S

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