4-Thiazoleacetic acid, a-(hydroxyiMino)-2-[(triphenylMethyl)aMino]-, ethyl ester

Base Information

• Chemical Name: 4-Thiazoleacetic acid, a-(hydroxyiMino)-2-[(triphenylMethyl)aMino]-, ethyl ester
• CAS No.: 78677-59-5
• Molecular Formula: C26H23N3O3S
• Molecular Weight: 457.553
• Mol file: 78677-59-5.mol

Synonyms:4-Thiazoleacetic acid, a-(hydroxyiMino)-2-[(triphenylMethyl)aMino]-, ethyl ester;Ethyl 2-(hydroxyimino)-2-(2-(tritylamino)thiazol-4-yl)acetate

Chemical Property of 4-Thiazoleacetic acid, a-(hydroxyiMino)-2-[(triphenylMethyl)aMino]-, ethyl ester

Chemical Property:

• PSA: 112.05000
• LogP: 5.36150

Purity/Quality:

98% ^*data from raw suppliers

Ethyl2-(hydroxyimino)-2-(2-(tritylamino)thiazol-4-yl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Thiazoleacetic acid, a-(hydroxyiMino)-2-[(triphenylMethyl)aMino]-, ethyl ester

There total 1 articles about 4-Thiazoleacetic acid, a-(hydroxyiMino)-2-[(triphenylMethyl)aMino]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Ethyl 2-(2-tritylaminothiazol-4-yl)-(Z)-2-(hydroxyimino)acetate (78677-59-5)

Guidance literature:

entspr. Amin, TRT-Cl;

Reference yield: 94.0%

Ethyl 2-(2-tritylaminothiazol-4-yl)-(Z)-2-(hydroxyimino)acetate (78677-59-5) + p-toluenesulfonyl chloride (98-59-9) → ethyl 2-(2-tritylaminothiazol-4-yl)-2-p-tosyloxyiminoacetate (138883-25-7)

Guidance literature:

With TEA; In tetrahydrofuran; for 3.5h; Ambient temperature;

DOI:10.1016/S0040-4020(01)96053-3

Reference yield: 32.0%

3-hydroxymethylpyridin (100-55-0) + Ethyl 2-(2-tritylaminothiazol-4-yl)-(Z)-2-(hydroxyimino)acetate (78677-59-5) → C32H28N4O3S

Guidance literature:

With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran; at 0 - 20 ℃;

Downstream raw materials:

ethyl 2-(2-tritylaminothiazol-4-yl)-2-p-tosyloxyiminoacetate

[5-Ethylsulfanyl-2-(trityl-amino)-thiazol-4-yl]-oxo-acetic acid ethyl ester

[5-Methoxycarbonylmethylsulfanyl-2-(trityl-amino)-thiazol-4-yl]-oxo-acetic acid ethyl ester

[5-Benzylsulfanyl-2-(trityl-amino)-thiazol-4-yl]-oxo-acetic acid ethyl ester

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