3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(3-((((3-(4-(3-methoxyphenyl)-1-piperidinyl)propyl)amino)carbonyl)amino)phenyl)-2,6-dimethyl-, 3,5-dimethyl ester

Base Information

Chemical Name:3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(3-((((3-(4-(3-methoxyphenyl)-1-piperidinyl)propyl)amino)carbonyl)amino)phenyl)-2,6-dimethyl-, 3,5-dimethyl ester
CAS No.:186185-03-5
Molecular Formula:C₃₃H₄₂N₄O₆
Molecular Weight:590.72
Hs Code.:
European Community (EC) Number:663-935-9
UNII:819SRG2Y6N
DSSTox Substance ID:DTXSID501018102
Nikkaji Number:J1.692.874G
Wikidata:Q27269229
Pharos Ligand ID:PAJVW5D787CQ
ChEMBL ID:CHEMBL324554
Mol file:186185-03-5.mol

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(3-((((3-(4-(3-methoxyphenyl)-1-piperidinyl)propyl)amino)carbonyl)amino)phenyl)-2,6-dimethyl-, 3,5-dimethyl ester

Synonyms:BMS 193885;BMS-193885;BMS193885

Suppliers and Price of 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(3-((((3-(4-(3-methoxyphenyl)-1-piperidinyl)propyl)amino)carbonyl)amino)phenyl)-2,6-dimethyl-, 3,5-dimethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
BMS 193885
10mg
$ 531.00

Tocris
BMS193885 ≥99%(HPLC)
50
$ 1088.00

Tocris
BMS193885 ≥99%(HPLC)
10
$ 271.00

Sigma-Aldrich
BMS-193885 ≥98% (HPLC)
5mg
$ 138.00

Sigma-Aldrich
BMS-193885 ≥98% (HPLC)
25mg
$ 550.00

American Custom Chemicals Corporation
BMS-193885 95.00%
50MG
$ 1478.35

American Custom Chemicals Corporation
BMS-193885 95.00%
10MG
$ 757.97

Total 5 raw suppliers

Chemical Property of 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(3-((((3-(4-(3-methoxyphenyl)-1-piperidinyl)propyl)amino)carbonyl)amino)phenyl)-2,6-dimethyl-, 3,5-dimethyl ester

Chemical Property:

Boiling Point:707.5±60.0 °C(Predicted)
PKA:13.94±0.46(Predicted)
PSA：121.72000
Density:1.188±0.06 g/cm3(Predicted)
LogP:5.21130
Storage Temp.:Desiccate at +4°C
Solubility.:DMSO: >10mg/mL
XLogP3:4.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:12
Exact Mass:590.31043507
Heavy Atom Count:43
Complexity:1010

Purity/Quality:

>98% ^*data from raw suppliers

BMS 193885 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC(=CC=C2)NC(=O)NCCCN3CCC(CC3)C4=CC(=CC=C4)OC)C(=O)OC
Uses BMS 193885, is a potent, and competitive neuropeptide (NPY) Y1 antagonist, that has also displayed 160-fold selectivity over σ1, α1, Y2, Y4 and Y5 receptors respectively. BMS 193885, is also brain penetrant, and able to reduce food intake and body weight through central Y1 inhibition.

Technology Process of 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(3-((((3-(4-(3-methoxyphenyl)-1-piperidinyl)propyl)amino)carbonyl)amino)phenyl)-2,6-dimethyl-, 3,5-dimethyl ester

There total 6 articles about 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(3-((((3-(4-(3-methoxyphenyl)-1-piperidinyl)propyl)amino)carbonyl)amino)phenyl)-2,6-dimethyl-, 3,5-dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 186185-87-5
4(3-Methoxyphenyl)piperidine-1-propanenitrile

: 186185-03-5
BMS-193885

Guidance literature:: Multi-step reaction with 2 steps

1: NH₃; H₂; Raney Ni / H₂O; methanol / 1 h / 2585.74 Torr

2: CH₂Cl₂ / 1 h

With ammonia; hydrogen; nickel; In methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2003.10.016

Reference yield:

: 99329-55-2
4-(3-methoxyphenyl)piperidine

: 186185-03-5
BMS-193885

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / acetonitrile / 4 h / Heating

2: NH₃; H₂; Raney Ni / H₂O; methanol / 1 h / 2585.74 Torr

3: CH₂Cl₂ / 1 h

With ammonia; hydrogen; nickel; In methanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmc.2003.10.016