N-Fmoc-(1-benzotriazolylcarbonyl)methylamine

Base Information

• Chemical Name: N-Fmoc-(1-benzotriazolylcarbonyl)methylamine
• CAS No.: 1082989-49-8
• Molecular Formula: C23H18N4O3
• Molecular Weight: 398.421
• Mol file: 1082989-49-8.mol

Synonyms:9H-Fluoren-9-yl)methyl 2-(1H-benzo[d][1,2,3]triazol-1-yl)-2-oxoethylcarbamate;N-Fmoc-(1-benzotriazolylcarbonyl)methylamine

Chemical Property of N-Fmoc-(1-benzotriazolylcarbonyl)methylamine

Chemical Property:

• Melting Point: 160-168°C
• PSA: 86.11000
• LogP: 4.00110
• Storage Temp.: ?20°C

Purity/Quality:

98%Min ^*data from raw suppliers

Fmoc-Gly-Bt 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Fmoc-(1-benzotriazolylcarbonyl)methylamine

There total 2 articles about N-Fmoc-(1-benzotriazolylcarbonyl)methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1,2,3-Benzotriazole (95-14-7,27556-51-0) + N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) → (9H-fluoren-9-yl)methyl (2-(1H-benzo[d][1,2,3]triazol-1-yl)-2-oxoethyl)carbamate (1082989-49-8)

Guidance literature:

1,2,3-Benzotriazole; With thionyl chloride; In tetrahydrofuran; at 25 ℃; for 0.5h; Inert atmosphere;

N-(fluoren-9-ylmethoxycarbonyl)glycine; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jo1015757

Reference yield:

1,2,3-Benzotriazole (95-14-7,27556-51-0) + 9H-fluoren-9-ylmethyl (2-chloro-2-oxoethyl)carbamate (103321-49-9) → (9H-fluoren-9-yl)methyl (2-(1H-benzo[d][1,2,3]triazol-1-yl)-2-oxoethyl)carbamate (1082989-49-8)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jo8026214

Reference yield: 91.0%

(9H-fluoren-9-yl)methyl (2-(1H-benzo[d][1,2,3]triazol-1-yl)-2-oxoethyl)carbamate (1082989-49-8) + aniline (62-53-3) → (9H-fluoren-9-yl)methyl [2-oxo-2-(phenylamino)ethyl]carbamate

Guidance literature:

In water; at 50 ℃; for 0.25h; Microwave irradiation; Green chemistry;

DOI:10.3390/molecules25112501

upstream raw materials:

1,2,3-Benzotriazole

9H-fluoren-9-ylmethyl (2-chloro-2-oxoethyl)carbamate

N-(fluoren-9-ylmethoxycarbonyl)glycine

Downstream raw materials:

H-Gly-NH₂

N-Fmoc-Gly-Phe-Cys(S-Fm)-OH

N-Fmoc-Gly-L-Cys(S-Z-L-Ala)-OH

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