2-Morpholinoacetaldehyde hydrochloride

Base Information

• Chemical Name: 2-Morpholinoacetaldehyde hydrochloride
• CAS No.: 1172495-88-3
• Molecular Formula: C6H12ClNO2
• Molecular Weight: 165.61798
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID00590794
• Mol file: 1172495-88-3.mol

Synonyms:2-Morpholinoacetaldehyde hydrochloride;1172495-88-3;2-(morpholin-4-yl)acetaldehyde hydrochloride;2-morpholin-4-ylacetaldehyde;hydrochloride;2-Morpholinoacetaldehydehydrochloride;DTXSID00590794;AMY38330;MFCD12022598;Morpholin-4-yl-acetaldehyde hydrochloride;DA-23089;Morpholin-4-yl-acetaldehyde hydrochloride, AldrichCPR;(Morpholin-4-yl)acetaldehyde--hydrogen chloride (1/1)

Chemical Property of 2-Morpholinoacetaldehyde hydrochloride

Chemical Property:

• PSA: 29.54000
• LogP: 0.25740
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 165.0556563
• Heavy Atom Count: 10
• Complexity: 89.1

Purity/Quality:

99% ^*data from raw suppliers

2-Morpholinoacetaldehydehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1CC=O.Cl

Technology Process of 2-Morpholinoacetaldehyde hydrochloride

There total 1 articles about 2-Morpholinoacetaldehyde hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2,2-dimethoxyethyl)morpholine (22633-57-4) → morpholin-4-yl-acetaldehyde hydrochloride (1172495-88-3)

Guidance literature:

With hydrogenchloride; In water; at 110 ℃; for 4.5h;

DOI:10.1021/jm5014659

Reference yield: 53.8%

morpholin-4-yl-acetaldehyde hydrochloride (1172495-88-3) + 4-{[6-(amino)quinolin-4-yl]oxy}-N-(pyridin-2-yl)benzamide → 4-[(6-{[2-(morpholin-4-yl)ethyl]amino}quinolin-4-yl)oxy]-N-(pyridin-2-yl)benzamide

Guidance literature:

With sodium cyanoborohydride; In ethanol; for 0.5h;

Reference yield: 27.0%

morpholin-4-yl-acetaldehyde hydrochloride (1172495-88-3) + diethyl (2-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)amino)-1-fluoro-2-oxoethyl)phosphonate (1420407-01-7) → (Z)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-2-fluoro-4-morpholinobut-2-enamide (1420404-24-5) + (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-2-fluoro-4-morpholinobut-2-enamide (1420404-28-9)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 0 - 20 ℃;

DOI:10.1021/jm5014659

upstream raw materials:

4-(2,2-dimethoxyethyl)morpholine

Downstream raw materials:

(Z)-(S)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-2-fluoro-4-morpholinobut-2-enamide

(E)-(S)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-2-fluoro-4-morpholinobut-2-enamide

(Z)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-2-fluoro-4-morpholinobut-2-enamide

(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-2-fluoro-4-morpholinobut-2-enamide

Refernces