(2S,3R,6RS)-2-(3-Oxobutyl)-3-Methyl-6-[(R)-2-propanal]cyclohexanone

Base Information

• Chemical Name: (2S,3R,6RS)-2-(3-Oxobutyl)-3-Methyl-6-[(R)-2-propanal]cyclohexanone
• CAS No.: 1093625-96-7
• Molecular Formula: C14H22O3
• Molecular Weight: 238.327
• Mol file: 1093625-96-7.mol

Synonyms:(2S,3R,6RS)-2-(3-Oxobutyl)-3-Methyl-6-[(R)-2-propanal]cyclohexanone;(2S,3R,6RS)-;Artemether Impurity 1

Chemical Property of (2S,3R,6RS)-2-(3-Oxobutyl)-3-Methyl-6-[(R)-2-propanal]cyclohexanone

Chemical Property:

• Boiling Point: 364.0±7.0 °C(Predicted)
• PSA: 51.21000
• Density: 0.992±0.06 g/cm3(Predicted)
• LogP: 2.42200
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

(2S,3R,6RS)-2-(3-Oxobutyl)-3-methyl-6-[(R)-2-propanal]cyclohexanoneMixtureofDiastereomers ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Artemether (A777400) impurity. Artemether (A777400) impurity. Artemisinin impurity

Technology Process of (2S,3R,6RS)-2-(3-Oxobutyl)-3-Methyl-6-[(R)-2-propanal]cyclohexanone

There total 4 articles about (2S,3R,6RS)-2-(3-Oxobutyl)-3-Methyl-6-[(R)-2-propanal]cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

10α-(4-benzylpiperazin-1-yl)-10-deoxoartemisinin (255730-31-5) → dihydroartemisinin (71939-50-9) + (R)-2-[(3S,4R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionaldehyde (1093625-96-7) + (3aS,4R,7S,7aR)-4-Methyl-7-((R)-1-methyl-2-oxo-ethyl)-hexahydro-benzofuran-7a-carbaldehyde

Guidance literature:

With hemin; L-Cysteine; In water; acetonitrile; at 23 ℃; for 24h; pH=7.4; Further Variations:; Reagents; Product distribution;

DOI:10.1002/anie.200352343

Reference yield:

C23H34N4O4 (694458-65-6) → (R)-2-[(3S,4R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionaldehyde (1093625-96-7) + (3aS,4R,7S,7aR)-4-Methyl-7-((R)-1-methyl-2-oxo-ethyl)-hexahydro-benzofuran-7a-carbaldehyde

Guidance literature:

With iron(II) sulfate; In water; acetonitrile; at 23 ℃; for 24h; Further Variations:; Reagents; Product distribution;

DOI:10.1002/anie.200352343

Reference yield:

dihydroartesiminin → C15H24O5 + (R)-2-[(3S,4R)-4-Methyl-2-oxo-3-(3-oxo-butyl)-cyclohexyl]-propionaldehyde (1093625-96-7)

Guidance literature:

at 120 ℃; for 1h; Pyrolysis;

DOI:10.1039/c4ra00879k

upstream raw materials:

dihydroartemisinin

C₂₃H₃₄N₄O₄

10α-(4-benzylpiperazin-1-yl)-10-deoxoartemisinin