(5α,11R,13β,19α)-1,2-Didehydrocrinan-11-ol

Base Information

Chemical Name:(5α,11R,13β,19α)-1,2-Didehydrocrinan-11-ol
CAS No.:561-19-3
Molecular Formula:C16H17NO3
Molecular Weight:271.31
Hs Code.:
Mol file:561-19-3.mol

Synonyms:(5α,11R,13β,19α)-1,2-Didehydrocrinan-11-ol;Demethoxycrinamine;Demethoxyhemanthamine;Hemultine

Suppliers and Price of (5α,11R,13β,19α)-1,2-Didehydrocrinan-11-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of (5α,11R,13β,19α)-1,2-Didehydrocrinan-11-ol

Chemical Property:

PSA：41.93000
LogP:1.49970

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5α,11R,13β,19α)-1,2-Didehydrocrinan-11-ol

There total 17 articles about (5α,11R,13β,19α)-1,2-Didehydrocrinan-11-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1422279-12-6
C₂₆H₂₄F₃NO₅

: 561-19-3
(+)-haemultine

Guidance literature:: C₂₆H₂₄F₃NO₅; With diisobutylaluminium hydride; In dichloromethane; at 18 ℃; for 3h; Inert atmosphere;

With ammonium chloride; In methanol; dichloromethane; water; Inert atmosphere;
DOI:10.1071/CH12473

Reference yield:

: 1262795-60-7
C₁₂H₁₃BrN₂O₄S

: 561-19-3
(+)-haemultine

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium carbonate

2.1: sodium hydride / N,N-dimethyl-formamide

3.1: palladium diacetate; N,N'-bis(benzyliden)ethylendiamine / benzene / 7 h / 80 °C

4.1: ozone / dichloromethane; methanol / 0.03 h / -78 °C

4.2: 0.5 h

5.1: thiophenol; caesium carbonate / acetonitrile / 0 - 18 °C / Inert atmosphere

5.2: 1 h / 0 - 18 °C

6.1: trifluoroacetic acid / 1,2-dichloro-ethane / 18 h / 60 °C

7.1: triethylamine; 2,4,6-trichlorobenzoyl chloride / tetrahydrofuran / 1.5 h / 18 °C / Inert atmosphere

7.2: 5 h / 90 - 105 °C / Inert atmosphere

8.1: diisobutylaluminium hydride / dichloromethane / 3 h / 18 °C / Inert atmosphere

8.2: Inert atmosphere

With N,N'-bis(benzyliden)ethylendiamine; 2,4,6-trichlorobenzoyl chloride; palladium diacetate; sodium hydride; diisobutylaluminium hydride; sodium carbonate; caesium carbonate; ozone; thiophenol; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; benzene; 1.1: |Suzuki-Miyaura Coupling / 6.1: |Pictet-Spengler Synthesis;
DOI:10.1071/CH12473

Reference yield:

: 1262795-62-9
C₁₉H₁₈N₂O₆S

: 561-19-3
(+)-haemultine

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide

2.1: palladium diacetate; N,N'-bis(benzyliden)ethylendiamine / benzene / 7 h / 80 °C

3.1: ozone / dichloromethane; methanol / 0.03 h / -78 °C

3.2: 0.5 h

4.1: thiophenol; caesium carbonate / acetonitrile / 0 - 18 °C / Inert atmosphere

4.2: 1 h / 0 - 18 °C

5.1: trifluoroacetic acid / 1,2-dichloro-ethane / 18 h / 60 °C

6.1: triethylamine; 2,4,6-trichlorobenzoyl chloride / tetrahydrofuran / 1.5 h / 18 °C / Inert atmosphere

6.2: 5 h / 90 - 105 °C / Inert atmosphere

7.1: diisobutylaluminium hydride / dichloromethane / 3 h / 18 °C / Inert atmosphere

7.2: Inert atmosphere

With N,N'-bis(benzyliden)ethylendiamine; 2,4,6-trichlorobenzoyl chloride; palladium diacetate; sodium hydride; diisobutylaluminium hydride; caesium carbonate; ozone; thiophenol; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; benzene; 5.1: |Pictet-Spengler Synthesis;
DOI:10.1071/CH12473