Pyrazino[1,2-a]indole, 1,2,3,4-tetrahydro-9-methyl- (9CI)

Base Information

• Chemical Name: Pyrazino[1,2-a]indole, 1,2,3,4-tetrahydro-9-methyl- (9CI)
• CAS No.: 796069-32-4
• Molecular Formula: C12H14N2
• Molecular Weight: 186.25296
• Mol file: 796069-32-4.mol

Synonyms:Pyrazino[1,2-a]indole, 1,2,3,4-tetrahydro-9-methyl- (9CI);9-METHYL-1,2,3,4-TETRAHYDROPYRAZINO[1,2-A]INDOLE

Chemical Property of Pyrazino[1,2-a]indole, 1,2,3,4-tetrahydro-9-methyl- (9CI)

Chemical Property:

• PSA: 16.96000
• LogP: 2.38170

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrazino[1,2-a]indole, 1,2,3,4-tetrahydro-9-methyl- (9CI)

There total 2 articles about Pyrazino[1,2-a]indole, 1,2,3,4-tetrahydro-9-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

1-cyanomethyl-4-methylindole-2-carboxylic acid ethyl ester (796069-25-5) → 9-methyl-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole (796069-32-4)

Guidance literature:

1-cyanomethyl-4-methylindole-2-carboxylic acid ethyl ester; With lithium aluminium tetrahydride; In diethyl ether; for 4h; Heating / reflux;

With water; ammonium chloride; In diethyl ether; ethyl acetate; at 80 ℃; for 0.166667h;

Reference yield:

ethyl 1-cyano-4-methylindole-2-carboxylate → 9-methyl-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole (796069-32-4)

Guidance literature:

Reference yield: 42.0%

9-methyl-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole (796069-32-4) + (2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester (791117-28-7) + 2-methoxy-5-trifluoromethylphenyl isocyanate (16588-75-3) → [8-fluoro-3-(2-methoxy-5-trifluoromethyl-phenyl)-2-(9-methyl-3,4-dihydro-1H-pyrazino[1,2-a]indol-2-yl)-3,4-dihydro-quinazolin-4-yl]acetic acid methyl ester (796069-35-7)

Guidance literature:

(2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester; 2-methoxy-5-trifluoromethylphenyl isocyanate; In dichloromethane; at 20 ℃;

9-methyl-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole; With silica gel; In 1,4-dioxane; dichloromethane; at 20 ℃; Heating / reflux;

upstream raw materials:

1-cyanomethyl-4-methylindole-2-carboxylic acid ethyl ester

Downstream raw materials:

[8-fluoro-3-(2-methoxy-5-trifluoromethyl-phenyl)-2-(9-methyl-3,4-dihydro-1H-pyrazino[1,2-a]indol-2-yl)-3,4-dihydro-quinazolin-4-yl]acetic acid methyl ester