1'-Epi 2',2'-Difluoro-2'-deoxyuridine 3',5'-Dibenzoate

Base Information

Chemical Name:1'-Epi 2',2'-Difluoro-2'-deoxyuridine 3',5'-Dibenzoate
CAS No.:143157-24-8
Molecular Formula:C23H18F2N2O7
Molecular Weight:472.3950264
Hs Code.:
Mol file:143157-24-8.mol

Synonyms:1'-Epi 2',2'-Difluoro-2'-deoxyuridine 3',5'-Dibenzoate;1-(3,5-Di-O-benzoyl-2-deoxy-2,2-difluoro-α-D-erythro-pentofuranosyl)-2,4(1H,3H)-pyriMidinedione

Suppliers and Price of 1'-Epi 2',2'-Difluoro-2'-deoxyuridine 3',5'-Dibenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1’-Epi2’,2’-Difluoro-2’-deoxyuridine3'',5''-Dibenzoate
250mg
$ 1320.00

Biosynth Carbosynth
1'-Epi 2',2'-difluoro-2'-deoxyuridine 3',5'-dibenzoate
250 mg
$ 1640.00

Biosynth Carbosynth
1'-Epi 2',2'-difluoro-2'-deoxyuridine 3',5'-dibenzoate
100 mg
$ 901.00

Biosynth Carbosynth
1'-Epi 2',2'-difluoro-2'-deoxyuridine 3',5'-dibenzoate
50 mg
$ 496.00

Biosynth Carbosynth
1'-Epi 2',2'-difluoro-2'-deoxyuridine 3',5'-dibenzoate
25 mg
$ 272.50

Biosynth Carbosynth
1'-Epi 2',2'-difluoro-2'-deoxyuridine 3',5'-dibenzoate
10 mg
$ 149.90

Total 3 raw suppliers

Chemical Property of 1'-Epi 2',2'-Difluoro-2'-deoxyuridine 3',5'-Dibenzoate

Chemical Property:

PSA：116.95000
LogP:2.56420
Solubility.:Dichloromethane, Methanol

Purity/Quality:

97% ^*data from raw suppliers

1’-Epi2’,2’-Difluoro-2’-deoxyuridine3'',5''-Dibenzoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Protected epimer of a Gemcitabine degradation product.

Technology Process of 1'-Epi 2',2'-Difluoro-2'-deoxyuridine 3',5'-Dibenzoate

There total 4 articles about 1'-Epi 2',2'-Difluoro-2'-deoxyuridine 3',5'-Dibenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₄F₂N₂O₈

: 143157-24-8
uridine

: 143157-27-1
((2R,3R,5R)-3-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4,4-difluorotetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: With hydrogenchloride; acetic acid; at 20 ℃; for 24h; Overall yield = 100 %; Overall yield = 125 mg;
DOI:10.1016/j.carres.2015.01.001

Reference yield:

: 890044-84-5
(2R,3R)-5-acetoxy-2-((benzoyloxy)methyl)-4,4-difluorotetrahydrofuran-3-yl benzoate

: 10457-14-4
O,O'-bis-(trimethylsilyl)uracil

: 143157-24-8
uridine

: 143157-27-1
((2R,3R,5R)-3-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4,4-difluorotetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: With tin(IV) chloride; In 1,2-dichloro-ethane; at 20 - 83 ℃; for 22h; Product distribution / selectivity;

Reference yield:

: 134877-42-2,134877-43-3,122111-11-9
3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose

: 10457-14-4
O,O'-bis-(trimethylsilyl)uracil

: 143157-24-8
uridine

: 143157-27-1
((2R,3R,5R)-3-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4,4-difluorotetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 83 ℃; for 17h; Product distribution / selectivity;