4'-(2-FLUOROPHENYL)PROPIOPHENONE

Base Information

• Chemical Name: 4'-(2-FLUOROPHENYL)PROPIOPHENONE
• CAS No.: 129159-23-5
• Molecular Formula: C₁₅H₁₃FO
• Molecular Weight: 228.266
• Mol file: 129159-23-5.mol

Synonyms:4'-(2-FLUOROPHENYL)PROPIOPHENONE;4-(2-FLUOROPHENYL)PROPIOPHENONE;AKOS BAR-2198;2-FLUORO-4'-PROPIONYLBIPHENYL;1-(2'-FLUORO[1,1'-BIPHENYL]-4-YL)PROPAN-1-ONE;1-(2'-Fluoro-biphenyl-4-yl)-propan-1-one

Chemical Property of 4'-(2-FLUOROPHENYL)PROPIOPHENONE

Chemical Property:

• Melting Point: 76-77°C
• PSA: 17.07000
• LogP: 4.08540

Purity/Quality:

99% ^*data from raw suppliers

1-(2-Fluoro-biphenyl-4-yl)-propan-1-one ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 4'-(2-FLUOROPHENYL)PROPIOPHENONE

There total 4 articles about 4'-(2-FLUOROPHENYL)PROPIOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

C18H22OSi → biphenyl-4-yl 1-fluoroethyl ketone (129159-23-5)

Guidance literature:

With N-fluoro-N-(phenylsulfonyl)-3,5-bis(trifluoromethyl)benzamide; In dichloromethane; at 25 ℃; for 24h; Inert atmosphere;

DOI:10.1002/chem.202101499

Reference yield: 83.0%

biphenyl-4-yl 1-hydroxyethyl ketone (7462-79-5) → biphenyl-4-yl 1-fluoroethyl ketone (129159-23-5)

Guidance literature:

With diethylamino-sulfur trifluoride; In dichloromethane; at 25 ℃; for 1h;

DOI:10.1039/P19900001683

Reference yield:

biphenyl (92-52-4,1594-86-1) + (R,S)-2-Fluoropropanoyl chloride (430-97-7) → biphenyl-4-yl 1-fluoroethyl ketone (129159-23-5)

Guidance literature:

With iron(III) chloride; In 1,2-dichloro-ethane; at 20 ℃; for 20h;

DOI:10.1055/s-1999-2921

upstream raw materials:

biphenyl-4-yl 1-hydroxyethyl ketone

biphenyl

(R,S)-2-Fluoropropanoyl chloride

2-Hydroxy-4'-phenylpropiophenone dimethylacetal