4-AMino-3-broMo-5-nitrobenzonitrile

Base Information

• Chemical Name: 4-AMino-3-broMo-5-nitrobenzonitrile
• CAS No.: 1239720-33-2
• Molecular Formula: C7H4BrN3O2
• Molecular Weight: 242.032
• Hs Code.: 2926909090
• Mol file: 1239720-33-2.mol

Synonyms:4-AMino-3-broMo-5-nitrobenzonitrile;2-Bromo-4-cyano-6-nitroaniline, 2-Amino-3-bromo-5-cyanonitrobenzene;4-Amino-3-bromo-5-nitrobenzonitrile 95%;4-Amino-3-bromo-5-nitrobenzonitrile95%

Chemical Property of 4-AMino-3-broMo-5-nitrobenzonitrile

Chemical Property:

• PSA: 95.63000
• LogP: 2.91558
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-3-bromo-5-nitrobenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMino-3-broMo-5-nitrobenzonitrile

There total 2 articles about 4-AMino-3-broMo-5-nitrobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2,2-difluoroacetic anhydride (401-67-2) + N-((4-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazol-6-yl)methyl)-5-(1H-tetrazol-5-yl)pyrimidin-2-amine → 4-amino-3-bromo-5-nitrobenzonitrile (1239720-33-2) + 5-(5-(difluoromethyl)-1,3,4-oxadiazol-2-yl)-N-((4-phenyl-1H-benzo[d]imidazol-6-yl)methyl)pyrimidin-2-amine

Guidance literature:

Reference yield: 35.0%

4-Amino 3-nitro-benzonitrile (6393-40-4) → 4-amino-3-bromo-5-nitrobenzonitrile (1239720-33-2)

Guidance literature:

With bromine; In acetic acid; at 15 - 20 ℃;

Reference yield: 70.0%

4-amino-3-bromo-5-nitrobenzonitrile (1239720-33-2) + 4-fluorobenzaldehyde (459-57-4) → C14H7BrFN3 (1239720-34-3)

Guidance literature:

With sodium dithionite; ethanol; at 150 ℃; for 0.75h; Microwave irradiation;

upstream raw materials:

4-Amino 3-nitro-benzonitrile

2,2-difluoroacetic anhydride

Downstream raw materials:

C₁₄H₇BrFN₃

4-bromo-1H-benzo[d]imidazole-6-carbonitrile

Refernces

• 1、 -. "NOVEL SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS GAMMA SECRETASE MODULATORS". Page/Page column 93-94. . Retrieved 2010/08/18.