2'-deoxythymidine-5'-(alpha-methylphosphonyl)-beta,gamma-diphosphate

Base Information

Chemical Name:2'-deoxythymidine-5'-(alpha-methylphosphonyl)-beta,gamma-diphosphate
CAS No.:138989-23-8
Molecular Formula:C₁₁H₁₉N₂O₁₃P₃
Molecular Weight:480.199
Hs Code.:
Mol file:138989-23-8.mol

Synonyms:2'-deoxythymidine-5'-(alpha-methylphosphonyl)-beta,gamma-diphosphate

Suppliers and Price of 2'-deoxythymidine-5'-(alpha-methylphosphonyl)-beta,gamma-diphosphate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of 2'-deoxythymidine-5'-(alpha-methylphosphonyl)-beta,gamma-diphosphate

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.779g/cm³

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

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Technology Process of 2'-deoxythymidine-5'-(alpha-methylphosphonyl)-beta,gamma-diphosphate

There total 2 articles about 2'-deoxythymidine-5'-(alpha-methylphosphonyl)-beta,gamma-diphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73264-62-7
5'-O-(methylphosphonyl)-2'-deoxythymidine

: 138989-23-8
5'-O-(α-methylphosphonyl)-β,γ-pyrophosphoryl-2'-deoxythymidine

Guidance literature:: 5'-O-(methylphosphonyl)-2'-deoxythymidine; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

With bis(tri-n-butylammonium) pyrophosphate; In N,N-dimethyl-formamide; at 20 ℃; Further stages.;
DOI:10.1021/ol006792j

Reference yield:

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

: 138989-23-8
5'-O-(α-methylphosphonyl)-β,γ-pyrophosphoryl-2'-deoxythymidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 47 percent Spectr_. / pyridine; 1,3-dicyclohexylcarbodiimide / 2 h / 45 °C

2.1: carbonyldiimidazole / dimethylformamide / 2 h / 20 °C

2.2: 18 percent Spectr_. / bis-(tri-n-butylammonium)pyrophosphate / dimethylformamide / 20 °C

With pyridine; dicyclohexyl-carbodiimide; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide;
DOI:10.1021/ol006792j