6-ISOPROPOXY-5-METHYLNICOTINIC ACID

Base Information

• Chemical Name: 6-ISOPROPOXY-5-METHYLNICOTINIC ACID
• CAS No.: 1011558-18-1
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.218
• Hs Code.: 2933399090
• Mol file: 1011558-18-1.mol

Synonyms:6-ISOPROPOXY-5-METHYLNICOTINIC ACID

Chemical Property of 6-ISOPROPOXY-5-METHYLNICOTINIC ACID

Chemical Property:

• PSA: 59.42000
• LogP: 1.87540
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

6-Isopropoxy-5-methylnicotinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-ISOPROPOXY-5-METHYLNICOTINIC ACID

There total 4 articles about 6-ISOPROPOXY-5-METHYLNICOTINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C11H15NO3 → 5-methyl-6-[(1-methylethyl)oxy]-3-pyridinecarboxylic acid (1011558-18-1)

Guidance literature:

With water; sodium hydroxide; In methanol; for 2h; Reflux;

Reference yield:

2-fluoro-3-methylpyridine-5-carboxylic acid (885267-35-6) → 5-methyl-6-[(1-methylethyl)oxy]-3-pyridinecarboxylic acid (1011558-18-1)

Guidance literature:

Multi-step reaction with 3 steps

1: diazomethyl-trimethyl-silane / diethyl ether / 1 h / 20 °C

2: sodium hydride / mineral oil; N,N-dimethyl-formamide / 3 h

3: water; sodium hydroxide / methanol / 2 h / Reflux

With water; sodium hydride; sodium hydroxide; diazomethyl-trimethyl-silane; In methanol; diethyl ether; N,N-dimethyl-formamide; mineral oil;

Reference yield:

methyl 6-fluoro-5-methylnicotinate (211122-38-2) → 5-methyl-6-[(1-methylethyl)oxy]-3-pyridinecarboxylic acid (1011558-18-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 3 h

2: water; sodium hydroxide / methanol / 2 h / Reflux

With water; sodium hydride; sodium hydroxide; In methanol; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

2-fluoro-3-methylpyridine-5-carboxylic acid

methyl 6-fluoro-5-methylnicotinate

Refernces

• 1、 -. "PYRIDINE DERIVATIVES AS S1P1/EDG1 RECEPTOR MODULATORS". Page/Page column 57. . Retrieved 2009/04/25.