(R)-1-Boc-2-(aMinoMethyl)-4,4-difluoropyrrolidine

Base Information

• Chemical Name: (R)-1-Boc-2-(aMinoMethyl)-4,4-difluoropyrrolidine
• CAS No.: 1407991-24-5
• Molecular Formula: C₁₀H₁₈F₂N₂O₂
• Molecular Weight: 236.262
• Mol file: 1407991-24-5.mol

Synonyms:(R)-1-Boc-2-(aMinoMethyl)-4,4-difluoropyrrolidine;tert-butyl (2R)-2-(aminomethyl)-4,4-difluoropyrrolidine-1-carboxylate;(R)-tert-Butyl 2-(aminomethyl)-4,4-difluoropyrrolidine-1-carboxylate

Chemical Property of (R)-1-Boc-2-(aMinoMethyl)-4,4-difluoropyrrolidine

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-1-Boc-2-(aminomethyl)-4,4-difluoropyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-Boc-2-(aMinoMethyl)-4,4-difluoropyrrolidine

There total 5 articles about (R)-1-Boc-2-(aMinoMethyl)-4,4-difluoropyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (S)-2-((1,3-dioxoisoindolin-2-yl)methyl)-4,4-difluoropyrrolidine-1-carboxylate → tert-butyl (2S)-2-(aminomethyl)-4,4-difluoropyrrolidine-1-carboxylate (1363384-67-1,1407991-24-5)

Guidance literature:

With hydrazine hydrate; In ethanol; at 60 ℃; for 2h;

Reference yield:

(S)-4,4-difluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylic acid tert-butyl ester (215918-21-1) → tert-butyl (2S)-2-(aminomethyl)-4,4-difluoropyrrolidine-1-carboxylate (1363384-67-1,1407991-24-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 10 - 20 °C

2: hydrazine hydrate / ethanol / 2 h / 60 °C

With di-isopropyl azodicarboxylate; hydrazine hydrate; triphenylphosphine; In tetrahydrofuran; ethanol;

Reference yield:

(S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate (102195-80-2) → tert-butyl (2S)-2-(aminomethyl)-4,4-difluoropyrrolidine-1-carboxylate (1363384-67-1,1407991-24-5)

Guidance literature:

Multi-step reaction with 4 steps

1: diethylamino-sulfur trifluoride / ethanol; dichloromethane / 18 h / 0 - 20 °C

2: lithium chloride; sodium tetrahydroborate / tetrahydrofuran; ethanol / 18 h / 0 - 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 10 - 20 °C

4: hydrazine hydrate / ethanol / 2 h / 60 °C

With sodium tetrahydroborate; diethylamino-sulfur trifluoride; di-isopropyl azodicarboxylate; hydrazine hydrate; triphenylphosphine; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane;

upstream raw materials:

(S)-4,4-difluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylic acid tert-butyl ester

(S)-1-tert-butyl 2-methyl 4-oxopyrrolidine-1,2-dicarboxylate

1-tert-butyl 2-methyl (2S)-4,4-difluoropyrrolidine-1,2-dicarboxylate

1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

Refernces