(E)-4-aMino-2-Methylbut-2-en-1-olhydrochloride

Base Information

• Chemical Name: (E)-4-aMino-2-Methylbut-2-en-1-olhydrochloride
• CAS No.: 128121-04-0
• Molecular Formula: C5H12ClNO
• Molecular Weight: 137.60788
• Mol file: 128121-04-0.mol

Synonyms:2-BUTEN-1-OL, 4-AMINO-2-METHYL-, HYDROCHLORIDE;(E)-4-AMINO-2-METHYLBUT-2-EN-1-OLHYDROCHLORIDE;

Chemical Property of (E)-4-aMino-2-Methylbut-2-en-1-olhydrochloride

Chemical Property:

• PSA: 46.25000
• LogP: 1.38600

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (E)-4-aMino-2-Methylbut-2-en-1-olhydrochloride

There total 3 articles about (E)-4-aMino-2-Methylbut-2-en-1-olhydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-tert-butyl (4-hydroxy-3-methylbut-2-en-1-yl)carbamate (128121-03-9) → (E) 4-amino-2-methylbut-2-en-1-ol-hydrochloride (128121-04-0)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 2h;

DOI:10.1021/ol026293d

Reference yield:

(E)-4-tert-butoxycarbonylamino-2-methylbut-2-enoic acid ethyl ester (356789-18-9) → (E) 4-amino-2-methylbut-2-en-1-ol-hydrochloride (128121-04-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / DIBAL-H / CH₂Cl₂; various solvent(s) / 2 h / -78 °C

2: 100 percent / HCl / H₂O / 2 h / 20 °C

With hydrogenchloride; diisobutylaluminium hydride; In dichloromethane; water;

DOI:10.1021/ol026293d

Reference yield:

(trans)-4-[(t-butoxycarbonyl)amino]-2-methyl-2-butenoic acid (128121-02-8) → (E) 4-amino-2-methylbut-2-en-1-ol-hydrochloride (128121-04-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.)EtOCOCl/Et₃N 2.)NaBH₄ / 1.) dry THF 2.) H₂O, 4h

2: 85 percent / 10percent aq. HCl / 1 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; chloroformic acid ethyl ester; triethylamine;

DOI:10.1016/0031-9422(90)80004-Z

upstream raw materials:

(E)-tert-butyl (4-hydroxy-3-methylbut-2-en-1-yl)carbamate

(E)-4-tert-butoxycarbonylamino-2-methylbut-2-enoic acid ethyl ester

(trans)-4-[(t-butoxycarbonyl)amino]-2-methyl-2-butenoic acid