Cyclopentanemethanol, 2-amino-4-fluoro-3-hydroxy-, [1S-(1alpha,2alpha,3beta,4beta)]- (9CI)

Base Information

Chemical Name:Cyclopentanemethanol, 2-amino-4-fluoro-3-hydroxy-, [1S-(1alpha,2alpha,3beta,4beta)]- (9CI)
CAS No.:160189-51-5
Molecular Formula:C₆H₁₂FNO₂
Molecular Weight:149.165
Hs Code.:
Mol file:160189-51-5.mol

Synonyms:Cyclopentanemethanol, 2-amino-4-fluoro-3-hydroxy-, [1S-(1alpha,2alpha,3beta,4beta)]- (9CI)

Suppliers and Price of Cyclopentanemethanol, 2-amino-4-fluoro-3-hydroxy-, [1S-(1alpha,2alpha,3beta,4beta)]- (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclopentanemethanol, 2-amino-4-fluoro-3-hydroxy-, [1S-(1alpha,2alpha,3beta,4beta)]- (9CI)

Chemical Property:

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Technology Process of Cyclopentanemethanol, 2-amino-4-fluoro-3-hydroxy-, [1S-(1alpha,2alpha,3beta,4beta)]- (9CI)

There total 4 articles about Cyclopentanemethanol, 2-amino-4-fluoro-3-hydroxy-, [1S-(1alpha,2alpha,3beta,4beta)]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 160189-52-6
(1S,2R,3S,5S)-2-benzyloxy-3-fluoro-5-hydroxymethylcyclopentylamine

: 160189-51-5
(1S,2R,3S,5S)-2-hydroxy-3-fluoro-5-hydroxymethylcyclopentylamine

Guidance literature:: With hydrogen; trifluoroacetic acid; palladium on activated charcoal;
DOI:10.1016/0957-4166(94)80052-9

Reference yield:

: (2R,3S)-2-benzyloxy-3-fluoro-5-hexenal oxime

: 160189-51-5
(1S,2R,3S,5S)-2-hydroxy-3-fluoro-5-hydroxymethylcyclopentylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / acetonitrile; dimethylformamide / 24 h / Heating

2: 84 percent / H₂ / PtO₂ / methanol / 1 h

3: 62 percent / TFA, H₂ / 10percent Pd/C

With hydrogen; trifluoroacetic acid; platinum(IV) oxide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/0957-4166(94)80052-9

Reference yield:

: 160189-49-1
(2aS,3R,4S,5aS)-3-benzyloxy-4-fluorocyclopentanoisoxazolidine

: 160189-51-5
(1S,2R,3S,5S)-2-hydroxy-3-fluoro-5-hydroxymethylcyclopentylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / H₂ / PtO₂ / methanol / 1 h

2: 62 percent / TFA, H₂ / 10percent Pd/C

With hydrogen; trifluoroacetic acid; platinum(IV) oxide; palladium on activated charcoal; In methanol;
DOI:10.1016/0957-4166(94)80052-9