trecetilide

Base Information

• Chemical Name: trecetilide
• CAS No.: 135124-45-7
• Molecular Formula: C21H37FN2O3S
• Molecular Weight: 416.598
• Mol file: 135124-45-7.mol

Synonyms:trecetilide

Chemical Property of trecetilide

Chemical Property:

• PSA: 78.02000
• LogP: 5.65590

Purity/Quality:

TRECETILIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trecetilide

There total 7 articles about trecetilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.3%

1-bromo-6-fluoro-6-methylheptane (135124-58-2) + N-[4-[4-(ethylamino)-1-hydroxybutyl]phenyl]methanesulfonamide (135124-51-5) → N-(4-(4-(Ethyl(6-fluoro-6-methylheptyl)amino)-1-hydroxybutyl)phenyl)methanesulfonamide (135124-45-7,180918-68-7)

Guidance literature:

With sodium hydrogencarbonate; In acetonitrile; for 16h; Heating;

DOI:10.1021/jm0004289

Reference yield:

6-hydroxy-6-methylheptyl THP ether (13129-62-9) → N-(4-(4-(Ethyl(6-fluoro-6-methylheptyl)amino)-1-hydroxybutyl)phenyl)methanesulfonamide (135124-45-7,180918-68-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 83.6 percent / DAST / CH₂Cl₂ / 0.42 h / -78 - 0 °C

2: 82.2 percent / pyridinium tosylate / ethanol / 41 h / 20 °C

3: 72.3 percent / NBS; Ph₃P / benzene / 5.5 h / 0 - 20 °C

4: 62.3 percent / NaHCO₃ / acetonitrile / 16 h / Heating

With N-Bromosuccinimide; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; triphenylphosphine; 4,4'-diaminostilbene-2,2'-disulfonic acid; In ethanol; dichloromethane; acetonitrile; benzene;

DOI:10.1021/jm0004289

Reference yield:

4-((methanesulfonyl)amino)-γ-oxobenzenebutanoic acid (100632-57-3) → N-(4-(4-(Ethyl(6-fluoro-6-methylheptyl)amino)-1-hydroxybutyl)phenyl)methanesulfonamide (135124-45-7,180918-68-7)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / tetrahydrofuran / 1.5 h / -12 °C

2: Et₃N / tetrahydrofuran / 3 h / -12 °C

3: 18.9 percent / LiAlH₄ / tetrahydrofuran / 21 h / 0 - 20 °C

4: 62.3 percent / NaHCO₃ / acetonitrile / 16 h / Heating

With lithium aluminium tetrahydride; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm0004289

upstream raw materials:

1-bromo-6-fluoro-6-methylheptane

N-[4-[4-(ethylamino)-1-hydroxybutyl]phenyl]methanesulfonamide

6-hydroxy-6-methylheptyl THP ether

4-((methanesulfonyl)amino)-γ-oxobenzenebutanoic acid

Refernces

• 1、 -. "Antiarrhythmic methanesulfonamides". . . Retrieved 2008/06/13.