(3R)-3-Hydroxy Quinine

Base Information

• Chemical Name: (3R)-3-Hydroxy Quinine
• CAS No.: 128241-59-8
• Molecular Formula: C₂₀H₂₄N₂O₃
• Molecular Weight: 340.422
• DSSTox Substance ID: DTXSID501258647
• Mol file: 128241-59-8.mol

Synonyms:128241-59-8;(3R)-3-Hydroxy Quinine;Cinchonan-3,9-diol, 6'-methoxy-, (3alpha,8alpha,9R)- (9CI);(3R,4S,6S)-3-ethenyl-6-[(R)-hydroxy-(6-methoxyquinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-3-ol;DTXSID501258647;Cinchonan-3,9-diol, 6'-methoxy-, (3alpha,8alpha,9R)-;Cinchonan-3,9-diol, 6'-methoxy-, (3alpha,8alpha,9R)-(9CI)

Chemical Property of (3R)-3-Hydroxy Quinine

Chemical Property:

• Melting Point: 114-116°C
• PSA: 54.82000
• LogP: 3.60840
• Solubility.: Chloroform, DMSO, Methanol
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 340.17869263
• Heavy Atom Count: 25
• Complexity: 501

Purity/Quality:

NLT 98% ^*data from raw suppliers

(3R)-3-HydroxyQuinine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4(C=C)O)O
• Isomeric SMILES: COC1=CC2=C(C=CN=C2C=C1)[C@H]([C@@H]3C[C@@H]4CCN3C[C@]4(C=C)O)O
• Uses: Isomer of (3R)-3-Hydroxy Quinine

Technology Process of (3R)-3-Hydroxy Quinine

There total 2 articles about (3R)-3-Hydroxy Quinine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

quinine (130-95-0) → (3R)-3-hydroxyquinine (128241-59-8) + (3S)-3-hydroxyquinine

Guidance literature:

Title compound not separated from byproducts.;

DOI:10.1021/np050015g

Reference yield:

→ 6'-methoxy-cinchonane-3,9-diol (53467-23-5,60761-51-5,78549-61-8,128241-59-8)

Guidance literature:

(8R,9S)-6-Methoxy-3-oxo-9-rubanolacetat (6), Vinylmagnesium bromid;

DOI:10.1016/S0040-4039(00)93775-4

upstream raw materials:

quinine